Bioremediation of a Common Product of Food Processing by a Human Gut Bacterium

Ashley R. Wolf, Darryl A. Wesener, Jiye Cheng, Alexandra N. Houston-Ludlam, Zachary W. Beller, Matthew C. Hibberd, Richard J. Giannone, Samantha L. Peters, Robert L. Hettich, Semen A. Leyn, Dmitry A. Rodionov, Andrei L. Osterman, Jeffrey I. Gordon

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Dramatic increases in processed food consumption represent a global health threat. Maillard reaction products (MRPs), which are common in processed foods, form upon heat-induced reaction of amino acids with reducing sugars and include advanced glycation end products with deleterious health effects. To examine how processed foods affect the microbiota, we fed gnotobiotic mice, colonized with 54 phylogenetically diverse human gut bacterial strains, defined sugar-rich diets containing whey as the protein source or a matched amino acid mixture. Whey or ϵ-fructoselysine, an MRP in whey and many processed foods, selectively increases Collinsella intestinalis absolute abundance and induces Collinsella expression of genomic loci directing import and metabolism of ϵ-fructoselysine to innocuous products. This locus is repressed by glucose in C. aerofaciens, whose abundance decreases with whey, but is not repressed in C. intestinalis. Identifying gut organisms responding to and degrading potentially harmful processed food components has implications for food science, microbiome science, and public health.

Original languageEnglish
Pages (from-to)463-477.e8
JournalCell Host and Microbe
Volume26
Issue number4
DOIs
StatePublished - Oct 9 2019

Keywords

  • Collinsella species
  • Maillard reaction products
  • gnotobiotic mice
  • human gut microbiome
  • processed foods
  • transcriptional and metabolic regulation

Fingerprint Dive into the research topics of 'Bioremediation of a Common Product of Food Processing by a Human Gut Bacterium'. Together they form a unique fingerprint.

  • Cite this

    Wolf, A. R., Wesener, D. A., Cheng, J., Houston-Ludlam, A. N., Beller, Z. W., Hibberd, M. C., Giannone, R. J., Peters, S. L., Hettich, R. L., Leyn, S. A., Rodionov, D. A., Osterman, A. L., & Gordon, J. I. (2019). Bioremediation of a Common Product of Food Processing by a Human Gut Bacterium. Cell Host and Microbe, 26(4), 463-477.e8. https://doi.org/10.1016/j.chom.2019.09.001