TY - JOUR
T1 - Bioplasmonic paper as a platform for detection of kidney cancer biomarkers
AU - Tian, Limei
AU - Morrissey, Jeremiah J.
AU - Kattumenu, Ramesh
AU - Gandra, Naveen
AU - Kharasch, Evan D.
AU - Singamaneni, Srikanth
PY - 2012/11/20
Y1 - 2012/11/20
N2 - We demonstrate that a common laboratory filter paper uniformly adsorbed with biofunctionalized plasmonic nanostructures can serve as a highly sensitive transduction platform for rapid detection of trace bioanalytes in physiological fluids. In particular, we demonstrate that bioplasmonic paper enables rapid urinalysis for the detection of kidney cancer biomarkers in artificial urine down to a concentration of 10 ng/mL. Compared to conventional rigid substrates, bioplasmonic paper offers numerous advantages such as high specific surface area (resulting in large dynamic range), excellent wicking properties (naturally microfluidic), mechanical flexibility, compatibility with conventional printing approaches (enabling multiplexed detection and multimarker biochips), and significant cost reduction.
AB - We demonstrate that a common laboratory filter paper uniformly adsorbed with biofunctionalized plasmonic nanostructures can serve as a highly sensitive transduction platform for rapid detection of trace bioanalytes in physiological fluids. In particular, we demonstrate that bioplasmonic paper enables rapid urinalysis for the detection of kidney cancer biomarkers in artificial urine down to a concentration of 10 ng/mL. Compared to conventional rigid substrates, bioplasmonic paper offers numerous advantages such as high specific surface area (resulting in large dynamic range), excellent wicking properties (naturally microfluidic), mechanical flexibility, compatibility with conventional printing approaches (enabling multiplexed detection and multimarker biochips), and significant cost reduction.
UR - http://www.scopus.com/inward/record.url?scp=84869474018&partnerID=8YFLogxK
U2 - 10.1021/ac302332g
DO - 10.1021/ac302332g
M3 - Article
C2 - 23098272
AN - SCOPUS:84869474018
SN - 0003-2700
VL - 84
SP - 9928
EP - 9934
JO - Analytical Chemistry
JF - Analytical Chemistry
IS - 22
ER -