Bioplasmonic paper as a platform for detection of kidney cancer biomarkers

Limei Tian, Jeremiah J. Morrissey, Ramesh Kattumenu, Naveen Gandra, Evan D. Kharasch, Srikanth Singamaneni

Research output: Contribution to journalArticlepeer-review

78 Scopus citations

Abstract

We demonstrate that a common laboratory filter paper uniformly adsorbed with biofunctionalized plasmonic nanostructures can serve as a highly sensitive transduction platform for rapid detection of trace bioanalytes in physiological fluids. In particular, we demonstrate that bioplasmonic paper enables rapid urinalysis for the detection of kidney cancer biomarkers in artificial urine down to a concentration of 10 ng/mL. Compared to conventional rigid substrates, bioplasmonic paper offers numerous advantages such as high specific surface area (resulting in large dynamic range), excellent wicking properties (naturally microfluidic), mechanical flexibility, compatibility with conventional printing approaches (enabling multiplexed detection and multimarker biochips), and significant cost reduction.

Original languageEnglish
Pages (from-to)9928-9934
Number of pages7
JournalAnalytical Chemistry
Volume84
Issue number22
DOIs
StatePublished - Nov 20 2012

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