Biomimetic polydopamine coating on gold nanorods for biofunctionalization, imaging, and photothermal therapy

Kvar C.L. Black, Ji Yi, José G. Rivera, Daria C. Zelasko-Leon, Phillip B. Messersmith

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

A biomimetic polydopamine (PD)-based strategy was employed for presenting antibodies on gold nanorods (NRs) to target cancer cells for photothermal therapy. PD was polymerized onto NRs, and epidermal growth factor receptor antibodies (anti-EGFR) were immobilized onto the layer. Anti-EGFR-PD-NRs specifically bound to EGFRoverexpressing cells as quantified by optical coherence tomography, and illumination enhanced cell death compared to non-irradiated or antibody-free controls.

Original languageEnglish
Title of host publicationBioinspired, Biointegrated, Bioengineered Photonic Devices
DOIs
StatePublished - 2013
EventBioinspired, Biointegrated, Bioengineered Photonic Devices - San Francisco, CA, United States
Duration: Feb 2 2013Feb 3 2013

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8598
ISSN (Print)1605-7422

Conference

ConferenceBioinspired, Biointegrated, Bioengineered Photonic Devices
Country/TerritoryUnited States
CitySan Francisco, CA
Period02/2/1302/3/13

Keywords

  • cancer
  • catecholamine
  • mussel adhesive proteins
  • optical imaging
  • photothermal therapy
  • plasmonic nanoparticles
  • polydopamine
  • surface plasmon resonance

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