Biomarkers to detect rejection after kidney transplantation

Research output: Contribution to journalReview article

Abstract

Detecting acute rejection in kidney transplantation has been traditionally done using histological analysis of invasive allograft biopsies, but this method carries a risk and is not perfect. Transplant professionals have been working to develop more accurate or less invasive biomarkers that can predict acute rejection or subsequent worse allograft survival. These biomarkers can use tissue, blood or urine as a source. They can comprise individual molecules or panels, singly or in combination, across different components or pathways of the immune system. This review highlights the most recent evidence for biomarker efficacy, especially from multicenter trials.

Original languageEnglish
Pages (from-to)1113-1122
Number of pages10
JournalPediatric Nephrology
Volume33
Issue number7
DOIs
StatePublished - Jul 1 2018

Keywords

  • Allograft loss
  • Biomarkers
  • Kidney
  • Pediatrics
  • Rejection
  • Transplant

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