Biomarkers of inflammation in heart failure

Biykem Bozkurt, Douglas L. Mann, Anita Deswal

Research output: Contribution to journalReview articlepeer-review

128 Scopus citations

Abstract

Heart failure (HF) is characterized by the elaboration of a portfolio of pro-inflammatory cytokines and inflammatory mediators that are considered to contribute to disease progression by virtue of the deleterious effects that these molecules exert on the heart and circulation. Recent studies have suggested that these inflammatory mediators may serve as relevant markers of disease severity and HF prognosis. Moreover, there is evidence that changes in the levels of inflammatory biomarkers may prove useful in following the change in patient clinical status following institution of appropriate HF therapy. This review will focus on the emerging role of inflammatory biomarkers, including pro-inflammatory cytokines, Creactive protein, and erythrocyte sedimentation rate in patients with HF.

Original languageEnglish
Pages (from-to)331-341
Number of pages11
JournalHeart Failure Reviews
Volume15
Issue number4
DOIs
StatePublished - Jul 1 2010
Externally publishedYes

Keywords

  • Biomarkers
  • C-reactive protein (CRP)
  • Chemokines
  • Cytokines
  • Erythrocyte sedimentation rate (ESR)
  • Heart failure
  • Inflammation
  • Interleukin-6 (IL-6)
  • Tumor necrosis factor (TNF)

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