Adult T-cell leukemia/lymphoma (ATL) is an aggressive lymphoproliferative malignancy with a very poor prognosis. Despite several recent advances, new therapeutic approaches are critical, and this will require successful preclinical studies, including studies in ATL cell culture systems, and mouse models. Identification of accurate, reproducible biomarkers will be a crucial component of preclinical and clinical studies. This review summarizes the current state-of-the-art in each of these fields, and provides recommendations for future approaches. This problem is an important unmet need in HTLV research.

Original languageEnglish
Article number2109
JournalFrontiers in Microbiology
StatePublished - Sep 18 2019


  • HBZ
  • adult T-cell leukemia-lymphoma
  • biomarkers
  • mouse models
  • preclinical
  • tax
  • xenograft


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