Biology of FasL

Hae Ock Lee; Thomas A. Ferguson

doi:10.1016/S1359-6101(03)00028-5

Biology of FasL

Hae Ock Lee, Thomas A. Ferguson

Research output: Contribution to journal › Review article › peer-review

62 Scopus citations

Abstract

FasL (CD95L) is a well-known and well-characterized death-inducing ligand. Spontaneous mutations in FasL and its cognate receptor Fas (CD95) have helped understand the role of these molecules in the disease. Once thought to be mainly involved in the homeostasis of immune system, the territory of FasL regulation has been expanded to angiogenesis and tumor progression. Here, we review what is currently known about the role of FasL in many areas of biology.

Original language	English
Pages (from-to)	325-335
Number of pages	11
Journal	Cytokine and Growth Factor Reviews
Volume	14
Issue number	3-4
DOIs	https://doi.org/10.1016/S1359-6101(03)00028-5
State	Published - 2003

Keywords

Angiogenesis
CTL
FasL
Immune privilege
Tumor progression

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10.1016/S1359-6101(03)00028-5

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title = "Biology of FasL",

abstract = "FasL (CD95L) is a well-known and well-characterized death-inducing ligand. Spontaneous mutations in FasL and its cognate receptor Fas (CD95) have helped understand the role of these molecules in the disease. Once thought to be mainly involved in the homeostasis of immune system, the territory of FasL regulation has been expanded to angiogenesis and tumor progression. Here, we review what is currently known about the role of FasL in many areas of biology.",

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AU - Lee, Hae Ock

AU - Ferguson, Thomas A.

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N2 - FasL (CD95L) is a well-known and well-characterized death-inducing ligand. Spontaneous mutations in FasL and its cognate receptor Fas (CD95) have helped understand the role of these molecules in the disease. Once thought to be mainly involved in the homeostasis of immune system, the territory of FasL regulation has been expanded to angiogenesis and tumor progression. Here, we review what is currently known about the role of FasL in many areas of biology.

AB - FasL (CD95L) is a well-known and well-characterized death-inducing ligand. Spontaneous mutations in FasL and its cognate receptor Fas (CD95) have helped understand the role of these molecules in the disease. Once thought to be mainly involved in the homeostasis of immune system, the territory of FasL regulation has been expanded to angiogenesis and tumor progression. Here, we review what is currently known about the role of FasL in many areas of biology.

KW - Angiogenesis

KW - CTL

KW - FasL

KW - Immune privilege

KW - Tumor progression

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U2 - 10.1016/S1359-6101(03)00028-5

DO - 10.1016/S1359-6101(03)00028-5

M3 - Review article

C2 - 12787569

AN - SCOPUS:0037982521

SN - 1359-6101

VL - 14

SP - 325

EP - 335

JO - Cytokine and Growth Factor Reviews

JF - Cytokine and Growth Factor Reviews

IS - 3-4

ER -

Biology of FasL

Abstract

Keywords

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