Biological Therapies of Immunologic Diseases: Strategies for Immunologic Interventions

Brooke I. Polk, Lanny J. Rosenwasser

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

The immune system possesses a vast number of potential targets for therapeutic intervention. Although therapies for many pathways have been pursued, only few have yielded significant success. Hindrances in altering biologic pathways include the potential for unwanted downstream effects, ineffectiveness owing to biological redundancy, recognition of a therapeutic molecule as foreign by the body's innate immune system, and the risks of subsequent malignancy and/or autoimmunity. This article covers currently available biotherapeutic agent classes as well as potential direction for future therapy.

Original languageEnglish
Pages (from-to)247-259
Number of pages13
JournalImmunology and Allergy Clinics of North America
Volume37
Issue number2
DOIs
StatePublished - May 1 2017
Externally publishedYes

Keywords

  • Biotherapeutic
  • Biotherapy
  • Immunomodulatory
  • Monoclonal antibody

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