Biological roles of adenine methylation in RNA

Konstantinos Boulias; Eric Lieberman Greer

doi:10.1038/s41576-022-00534-0

Biological roles of adenine methylation in RNA

Konstantinos Boulias
, Eric Lieberman Greer

Research output: Contribution to journal › Review article › peer-review

294 Scopus citations

Abstract

N⁶-Methyladenosine (m⁶A) is one of the most abundant modifications of the epitranscriptome and is found in cellular RNAs across all kingdoms of life. Advances in detection and mapping methods have improved our understanding of the effects of m⁶A on mRNA fate and ribosomal RNA function, and have uncovered novel functional roles in virtually every species of RNA. In this Review, we explore the latest studies revealing roles for m⁶A-modified RNAs in chromatin architecture, transcriptional regulation and genome stability. We also summarize m⁶A functions in biological processes such as stem-cell renewal and differentiation, brain function, immunity and cancer progression.

Original language	English
Pages (from-to)	143-160
Number of pages	18
Journal	Nature Reviews Genetics
Volume	24
Issue number	3
DOIs	https://doi.org/10.1038/s41576-022-00534-0
State	Published - Mar 2023

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Biological roles of adenine methylation in RNA

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