TY - JOUR
T1 - Biological roles of adenine methylation in RNA
AU - Boulias, Konstantinos
AU - Greer, Eric Lieberman
N1 - Funding Information:
Work from the Greer laboratory is supported by grants from the US National Institutes of Health (NIH) (DP2AG055947 and R01AI151215). The authors apologize for literature omitted owing to space limitations.
Publisher Copyright:
© 2022, Springer Nature Limited.
PY - 2023/3
Y1 - 2023/3
N2 - N6-Methyladenosine (m6A) is one of the most abundant modifications of the epitranscriptome and is found in cellular RNAs across all kingdoms of life. Advances in detection and mapping methods have improved our understanding of the effects of m6A on mRNA fate and ribosomal RNA function, and have uncovered novel functional roles in virtually every species of RNA. In this Review, we explore the latest studies revealing roles for m6A-modified RNAs in chromatin architecture, transcriptional regulation and genome stability. We also summarize m6A functions in biological processes such as stem-cell renewal and differentiation, brain function, immunity and cancer progression.
AB - N6-Methyladenosine (m6A) is one of the most abundant modifications of the epitranscriptome and is found in cellular RNAs across all kingdoms of life. Advances in detection and mapping methods have improved our understanding of the effects of m6A on mRNA fate and ribosomal RNA function, and have uncovered novel functional roles in virtually every species of RNA. In this Review, we explore the latest studies revealing roles for m6A-modified RNAs in chromatin architecture, transcriptional regulation and genome stability. We also summarize m6A functions in biological processes such as stem-cell renewal and differentiation, brain function, immunity and cancer progression.
UR - http://www.scopus.com/inward/record.url?scp=85140105228&partnerID=8YFLogxK
U2 - 10.1038/s41576-022-00534-0
DO - 10.1038/s41576-022-00534-0
M3 - Review article
C2 - 36261710
AN - SCOPUS:85140105228
SN - 1471-0056
VL - 24
SP - 143
EP - 160
JO - Nature Reviews Genetics
JF - Nature Reviews Genetics
IS - 3
ER -