Biological Phenotyping in Sepsis and Acute Respiratory Distress Syndrome

Pratik Sinha, Nuala J. Meyer, Carolyn S. Calfee

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations


Heterogeneity in sepsis and acute respiratory distress syndrome (ARDS) is increasingly being recognized as one of the principal barriers to finding efficacious targeted therapies. The advent of multiple high-Throughput biological data ( quot omics quot ), coupled with the widespread access to increased computational power, has led to the emergence of phenotyping in critical care. Phenotyping aims to use a multitude of data to identify homogenous subgroups within an otherwise heterogenous population. Increasingly, phenotyping schemas are being applied to sepsis and ARDS to increase understanding of these clinical conditions and identify potential therapies. Here we present a selective review of the biological phenotyping schemas applied to sepsis and ARDS. Further, we outline some of the challenges involved in translating these conceptual findings to bedside clinical decision-making tools.

Original languageEnglish
Pages (from-to)457-471
Number of pages15
JournalAnnual review of medicine
StatePublished - Jan 27 2023


  • ARDS
  • acute respiratory distress syndrome
  • critical care
  • phenotypes
  • precision medicine
  • sepsis
  • subphenotypes


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