Biological enhancement of bone graft materials by osteogenic factors

Stephen D. Cook, Robert L. Barrack

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations


The number and complexity of total hip arthroplasty cases continues to increase. The challenges of complex hip arthroplasty include bone loss in the proximal femurand acetabulum as well as deformity, cortex perforation, and periprosthetic fracture. The use of bone graft material has become routine in many of these cases [1-3]. The added surgical time, limited supply, and morbidity associated with the autogenous bone graft harvest has resulted in the use of various types of allograft bone in the vast majority of cases. Contained defects are effectively managed with morselized cancellous allograft. While allograft bone can heal defects, ingrowth does not occur from the defect to a porous ingrowth surface. This can compromise component stability if extensivedefects are present. In addition, when there is a need for immediate structural support, cortical allografts are often used, which have a much slower rate of incorporation.

Original languageEnglish
Title of host publicationImpaction Bone Grafting in Revision Arthroplasty
PublisherCRC Press
Number of pages12
ISBN (Electronic)9780203913680
ISBN (Print)9780824747992
StatePublished - Jan 1 2004


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