TY - JOUR
T1 - Biological consequences of gene regulation after ionizing radiation exposure
AU - Weichselbaum, Ralph R.
AU - Hallahan, Dennis E.
AU - Sukhatme, Vikas
AU - Dritschilo, Anatoly
AU - Sherman, Matthew L.
AU - Kufe, Donald W.
N1 - Funding Information:
Received October 2, 1990; revised January 22, 1991; accepted January 24, 1991. Supported by Public Health Service grants CA-42596 and CA-41068 from the National Cancer Institute, National Institutes of Health, Department of Health and Human Services; by The Chicago Tumor Institute; and by The Center for Radiation Therapy. R. R. Weichselbaum, D. E. Hallahan, V. Sukhatme, Department of Radiation and Cellular Oncology and Department of Medicine, University of Chicago Hospitals and Clinics, Chicago, 111. A. Dritschilo, Georgetown University Medical Center, Washington, DC. M. L. Sherman, D. W. Kufe, Laboratory of Clinical Pharmacology, Dana-Far-ber Cancer Institute, Boston, Mass. *Corrcspondence to: Ralph R. Weichselbaum, MD, Department of Radiation and Cellular Oncology, University of Chicago, 5841 S Maryland, Chicago, IL 60637.
PY - 1991/4/3
Y1 - 1991/4/3
N2 - Ionizing radiation is a ubiquitous environmental mutagen and carcinogen widely used in cancer therapy. However, little is known about the induction of cellular signaling events and specific gene expression after radiation exposure. We review the accumulating evidence that ionizing radiation induces signal transduction pathways involving activation of protein kinase C and a program of genetic events that may contribute to the biological effects of x rays. [J Natl Cancer Inst 83:480-484, 1991].
AB - Ionizing radiation is a ubiquitous environmental mutagen and carcinogen widely used in cancer therapy. However, little is known about the induction of cellular signaling events and specific gene expression after radiation exposure. We review the accumulating evidence that ionizing radiation induces signal transduction pathways involving activation of protein kinase C and a program of genetic events that may contribute to the biological effects of x rays. [J Natl Cancer Inst 83:480-484, 1991].
UR - http://www.scopus.com/inward/record.url?scp=0025911273&partnerID=8YFLogxK
U2 - 10.1093/jnci/83.7.480
DO - 10.1093/jnci/83.7.480
M3 - Review article
C2 - 2005631
AN - SCOPUS:0025911273
SN - 0027-8874
VL - 83
SP - 480
EP - 484
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
IS - 7
ER -