Biological consequences of gene regulation after ionizing radiation exposure

Ralph R. Weichselbaum, Dennis E. Hallahan, Vikas Sukhatme, Anatoly Dritschilo, Matthew L. Sherman, Donald W. Kufe

Research output: Contribution to journalReview articlepeer-review

148 Scopus citations


Ionizing radiation is a ubiquitous environmental mutagen and carcinogen widely used in cancer therapy. However, little is known about the induction of cellular signaling events and specific gene expression after radiation exposure. We review the accumulating evidence that ionizing radiation induces signal transduction pathways involving activation of protein kinase C and a program of genetic events that may contribute to the biological effects of x rays. [J Natl Cancer Inst 83:480-484, 1991].

Original languageEnglish
Pages (from-to)480-484
Number of pages5
JournalJournal of the National Cancer Institute
Issue number7
StatePublished - Apr 3 1991


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