TY - JOUR
T1 - Biological age is better than chronological as predictor of 3-month outcome in ischemic stroke
AU - Soriano-Tárraga, Carolina
AU - Mola-Caminal, Marina
AU - Giralt-Steinhauer, Eva
AU - Ois, Angel
AU - Rodríguez-Campello, Ana
AU - Cuadrado-Godia, Elisa
AU - Gómez-González, Alejandra
AU - Vivanco-Hidalgo, Rosa M.
AU - Fernández-Cadenas, Israel
AU - Cullell, Natalia
AU - Roquer, Jaume
AU - Jiménez-Conde, Jordi
N1 - Publisher Copyright:
© 2017 American Academy of Neurology.
PY - 2017/8/22
Y1 - 2017/8/22
N2 - Objective: To analyze the effect of age-related DNA methylation changes in multiple cytosine-phosphate-guanine (CpG) sites (biological age [b-age]) on patient outcomes at 3 months after an ischemic stroke. Methods: We included 511 patients with first-ever acute ischemic stroke assessed at Hospital del Mar (Barcelona, Spain) as the discovery cohort. Demographic and clinical data, including chronological age (c-age), vascular risk factors, initial stroke severity, recanalization treatment, and previous and 3-month modified Rankin Scale (p-mRS and 3-mRS, respectively) were registered. B-age was estimated with an algorithm, based on DNA methylation in 71 CpGs. Bivariate analysis determined variables associated with 3-mRS for inclusion in ordinal multivariate analysis. Results: After ordinal regressions for 3-month ischemic stroke outcome (3-mRS), b-age was associated with outcome (odds ratio 1.04 [95% confidence interval 1.01-1.07]), nullifying c-age. Stepwise regression kept b-age, basal NIH Stroke Scale, sex, p-mRS, and recanalization treatment as better explanatory variables, instead of c-age. These results were successfully replicated in an independent cohort. Conclusions: B-age, estimated by DNA methylation, is an independent predictor of ischemic stroke outcome regardless of chronological years.
AB - Objective: To analyze the effect of age-related DNA methylation changes in multiple cytosine-phosphate-guanine (CpG) sites (biological age [b-age]) on patient outcomes at 3 months after an ischemic stroke. Methods: We included 511 patients with first-ever acute ischemic stroke assessed at Hospital del Mar (Barcelona, Spain) as the discovery cohort. Demographic and clinical data, including chronological age (c-age), vascular risk factors, initial stroke severity, recanalization treatment, and previous and 3-month modified Rankin Scale (p-mRS and 3-mRS, respectively) were registered. B-age was estimated with an algorithm, based on DNA methylation in 71 CpGs. Bivariate analysis determined variables associated with 3-mRS for inclusion in ordinal multivariate analysis. Results: After ordinal regressions for 3-month ischemic stroke outcome (3-mRS), b-age was associated with outcome (odds ratio 1.04 [95% confidence interval 1.01-1.07]), nullifying c-age. Stepwise regression kept b-age, basal NIH Stroke Scale, sex, p-mRS, and recanalization treatment as better explanatory variables, instead of c-age. These results were successfully replicated in an independent cohort. Conclusions: B-age, estimated by DNA methylation, is an independent predictor of ischemic stroke outcome regardless of chronological years.
UR - https://www.scopus.com/pages/publications/85027833157
U2 - 10.1212/WNL.0000000000004261
DO - 10.1212/WNL.0000000000004261
M3 - Article
C2 - 28733340
AN - SCOPUS:85027833157
SN - 0028-3878
VL - 89
SP - 830
EP - 836
JO - Neurology
JF - Neurology
IS - 8
ER -