Biodistribution and Radiation Dosimetry of the Enterobacteriaceae-Specific Imaging Probe [18F]Fluorodeoxysorbitol Determined by PET/CT in Healthy Human Volunteers

Wenjia Zhu, Shaobo Yao, Haiqun Xing, Hui Zhang, Yuan chuan Tai, Yingqiang Zhang, Yimin Liu, Yanru Ma, Chenxi Wu, Hongkai Wang, Zibo Li, Zhanhong Wu, Zhaohui Zhu, Fang Li, Li Huo

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Purpose: [18F]fluorodeoxysorbitol ([18F]FDS) is the first radiopharmaceutical specific for a category of bacteria and has the potential to specifically detect Enterobacteriaceae infections. The purpose of this study was to testify the safety and investigate the biodistribution and radiation dosimetry of [18F]FDS in healthy human bodies. Procedures: Six healthy subjects were intravenously injected with 320–520 MBq [18F]FDS. On each subject, 21 whole-body emission scans and a brain scan were conducted at settled time points within the next 4 h. Residence time for each source organ was determined by multi-exponential regression. Absorbed doses for target organs and effective dose were calculated via OLINDA/EXM. Results: No adverse events due to [18F]FDS injection were observed in the study. The tracer was cleared rapidly from the blood pool through the urinary system. A small portion was cleared into the gut through the hepatobiliary system. The effective dose (ED) was estimated to be 0.021 ± 0.001 mSv/MBq. The organ receiving the highest absorbed dose was the urinary bladder wall (0.25 ± 0.03 mSv/MBq). Conclusions: [18F]FDS is safe and well tolerated. The effective dose was comparable to that of other F-18 labeled radiotracers. [18F]FDS is suitable for human use from a radiation dosimetry perspective.

Original languageEnglish
Pages (from-to)782-787
Number of pages6
JournalMolecular Imaging and Biology
Volume18
Issue number5
DOIs
StatePublished - Oct 1 2016

Keywords

  • Biodistribution
  • Enterobacteriaceae
  • PET
  • Radiation dosimetry
  • [F] FDS

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