TY - JOUR
T1 - Bioconversion of renewable feedstocks by Rhodococcus opacus
AU - Chatterjee, Anamika
AU - DeLorenzo, Drew M.
AU - Carr, Rhiannon
AU - Moon, Tae Seok
N1 - Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2020/8
Y1 - 2020/8
N2 - The production of fuels and chemicals from renewable feedstocks is necessary for a fossil fuel independent economy. Lignin and other industrial wastes represent sustainable, non-food feedstocks that can be tapped for microbe-based bioproduction. Rhodococcus opacus is a gram-positive bacterium capable of catabolizing a broad range of feedstocks, and recent technological advances have further established its potential for lignin and industrial waste valorization. In the process of developing R. opacus as a platform for bioproduction, metabolic profiling has elucidated its native mechanisms of bioconversion, adaptive evolution has enhanced its tolerance towards inhibitory feedstocks, and genetic engineering has enabled it to produce novel products, such as wax esters, free fatty acids, and long chain hydrocarbons. Here, we present recent examples of broad feedstock utilization and value-added chemical production by R. opacus, demonstrating its potential as an industrially relevant strain.
AB - The production of fuels and chemicals from renewable feedstocks is necessary for a fossil fuel independent economy. Lignin and other industrial wastes represent sustainable, non-food feedstocks that can be tapped for microbe-based bioproduction. Rhodococcus opacus is a gram-positive bacterium capable of catabolizing a broad range of feedstocks, and recent technological advances have further established its potential for lignin and industrial waste valorization. In the process of developing R. opacus as a platform for bioproduction, metabolic profiling has elucidated its native mechanisms of bioconversion, adaptive evolution has enhanced its tolerance towards inhibitory feedstocks, and genetic engineering has enabled it to produce novel products, such as wax esters, free fatty acids, and long chain hydrocarbons. Here, we present recent examples of broad feedstock utilization and value-added chemical production by R. opacus, demonstrating its potential as an industrially relevant strain.
UR - http://www.scopus.com/inward/record.url?scp=85072704703&partnerID=8YFLogxK
U2 - 10.1016/j.copbio.2019.08.013
DO - 10.1016/j.copbio.2019.08.013
M3 - Review article
C2 - 31580993
AN - SCOPUS:85072704703
SN - 0958-1669
VL - 64
SP - 10
EP - 16
JO - Current Opinion in Biotechnology
JF - Current Opinion in Biotechnology
ER -