Biocompatibilities of sapphire and borosilicate glass as cortical neuroprostheses

Kaushik S. Parthasarathy; Yu Chung N. Cheng; J. Patterson McAllister; Yimin Shen; Jie Li; Kelley Deren; E. Mark Haacke; Gregory W. Auner

doi:10.1016/j.mri.2007.03.020

Biocompatibilities of sapphire and borosilicate glass as cortical neuroprostheses

Kaushik S. Parthasarathy, Yu Chung N. Cheng, J. Patterson McAllister, Yimin Shen, Jie Li, Kelley Deren, E. Mark Haacke, Gregory W. Auner

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The in vivo biocompatibility of pure sapphire and borosilicate glass (BSG) implanted onto the cerebral cortex was studied via magnetic resonance imaging (MRI) and histopathology. Each implant was embedded onto the cortical surface of an adult rat brain for a total of 28 days. Rats underwent surgery with and without implants, and rats with purposely damaged cortical implant sites were also studied. Each animal was imaged via MRI before surgery as well as 10 and 28 days after the surgery. Histopathological results of animals were obtained on the 28th day to determine the specific effect on neurons. Despite the fact that sapphire has been widely used in a variety of medical implants, both MRI and histopathological results indicate that pure sapphire is not biocompatible with the cerebral cortex. On the contrary, BSG implants appear to be biocompatible with the cortical surface.

Original language	English
Pages (from-to)	1333-1340
Number of pages	8
Journal	Magnetic Resonance Imaging
Volume	25
Issue number	9
DOIs	https://doi.org/10.1016/j.mri.2007.03.020
State	Published - Nov 2007

Keywords

Biocompatibility
Borosilicate glass
Cerebral cortex
Image analysis
Neural prosthesis
Sapphire

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10.1016/j.mri.2007.03.020

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@article{a8c658682607455698db091caef14cb4,

title = "Biocompatibilities of sapphire and borosilicate glass as cortical neuroprostheses",

abstract = "The in vivo biocompatibility of pure sapphire and borosilicate glass (BSG) implanted onto the cerebral cortex was studied via magnetic resonance imaging (MRI) and histopathology. Each implant was embedded onto the cortical surface of an adult rat brain for a total of 28 days. Rats underwent surgery with and without implants, and rats with purposely damaged cortical implant sites were also studied. Each animal was imaged via MRI before surgery as well as 10 and 28 days after the surgery. Histopathological results of animals were obtained on the 28th day to determine the specific effect on neurons. Despite the fact that sapphire has been widely used in a variety of medical implants, both MRI and histopathological results indicate that pure sapphire is not biocompatible with the cerebral cortex. On the contrary, BSG implants appear to be biocompatible with the cortical surface.",

keywords = "Biocompatibility, Borosilicate glass, Cerebral cortex, Image analysis, Neural prosthesis, Sapphire",

author = "Parthasarathy, {Kaushik S.} and Cheng, {Yu Chung N.} and McAllister, {J. Patterson} and Yimin Shen and Jie Li and Kelley Deren and Haacke, {E. Mark} and Auner, {Gregory W.}",

note = "Funding Information: The authors would like to thank Claudine Jaboro for her help in the preparations of implants. Y.-C.N. Cheng would like to thank Mr. Srinivasu Kallakuri for his helpful discussions of the manuscript and Mr. Prithvi Gopinath for the preparation of the figures. J.P. McAllister would like to thank Janet M. Miller, Ph.D., for her help with the surgery and histology. This project is partially supported by the Michigan Life Sciences Corridor Fund.",

year = "2007",

month = nov,

doi = "10.1016/j.mri.2007.03.020",

language = "English",

volume = "25",

pages = "1333--1340",

journal = "Magnetic Resonance Imaging",

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AU - Shen, Yimin

AU - Li, Jie

AU - Deren, Kelley

AU - Haacke, E. Mark

AU - Auner, Gregory W.

N1 - Funding Information: The authors would like to thank Claudine Jaboro for her help in the preparations of implants. Y.-C.N. Cheng would like to thank Mr. Srinivasu Kallakuri for his helpful discussions of the manuscript and Mr. Prithvi Gopinath for the preparation of the figures. J.P. McAllister would like to thank Janet M. Miller, Ph.D., for her help with the surgery and histology. This project is partially supported by the Michigan Life Sciences Corridor Fund.

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N2 - The in vivo biocompatibility of pure sapphire and borosilicate glass (BSG) implanted onto the cerebral cortex was studied via magnetic resonance imaging (MRI) and histopathology. Each implant was embedded onto the cortical surface of an adult rat brain for a total of 28 days. Rats underwent surgery with and without implants, and rats with purposely damaged cortical implant sites were also studied. Each animal was imaged via MRI before surgery as well as 10 and 28 days after the surgery. Histopathological results of animals were obtained on the 28th day to determine the specific effect on neurons. Despite the fact that sapphire has been widely used in a variety of medical implants, both MRI and histopathological results indicate that pure sapphire is not biocompatible with the cerebral cortex. On the contrary, BSG implants appear to be biocompatible with the cortical surface.

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Biocompatibilities of sapphire and borosilicate glass as cortical neuroprostheses

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Keywords

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