TY - JOUR
T1 - Biochemistry and pharmacology of renal arachidonic acid metabolism
AU - Morrison, Aubrey R.
N1 - Funding Information:
From the Department of Medicine and Pharmacology, Washington University School of Medicine, St. Louis, Missouri. This work is supported by Public Health Service award AM-30542. Dr. Morrison is an established investigator of the American Heart Association. Requests for reprints should be addressed to Dr. Aubrey R. Morrison, Department of Pharmacology, Washington University School of Medicine, 660 South Euclid, St. Louis, Missouri 63110.
PY - 1986/1/17
Y1 - 1986/1/17
N2 - Arachidonic acid is metabolized to prostaglandin, lipoxygenase products, and products of the microsomal cytochrome P-450 enzymes of the kidney. The distribution of the metabolizing enzymes and their regulation and pharmacologic manipulation are reviewed. The mechanisms of release of arachidonic acid from membrane lipids through a surface-mediated receptor mechanism are also discussed. The localization of the various enzymes and product formation may have profound effects on glomerular filtration, renal blood flow, and electrolyte excretion. Therefore, an understanding of the potential sites of inhibition of the nonsteroidal anti-inflammatory drugs is important in assessing their effects on renal function.
AB - Arachidonic acid is metabolized to prostaglandin, lipoxygenase products, and products of the microsomal cytochrome P-450 enzymes of the kidney. The distribution of the metabolizing enzymes and their regulation and pharmacologic manipulation are reviewed. The mechanisms of release of arachidonic acid from membrane lipids through a surface-mediated receptor mechanism are also discussed. The localization of the various enzymes and product formation may have profound effects on glomerular filtration, renal blood flow, and electrolyte excretion. Therefore, an understanding of the potential sites of inhibition of the nonsteroidal anti-inflammatory drugs is important in assessing their effects on renal function.
UR - http://www.scopus.com/inward/record.url?scp=0022574593&partnerID=8YFLogxK
U2 - 10.1016/0002-9343(86)90927-7
DO - 10.1016/0002-9343(86)90927-7
M3 - Article
C2 - 3080877
AN - SCOPUS:0022574593
SN - 0002-9343
VL - 80
SP - 3
EP - 11
JO - The American journal of medicine
JF - The American journal of medicine
IS - 1 SUPPL. 1
ER -