Biochemistry and biology of antigen presentation by macrophages

Emil R. Unanue, Paul M. Allen

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

The presentation of antigen by macrophages has been studied. We have shown that globular proteins must be processed in endocytic vesicles of low pH prior to presentation. Some of the structural requirements of one such processed peptide have been determined, as has the affinity for Ia of that peptide. Finally, we have shown that a membrane-associated form of interleukin-1 is also required for presentation of processed antigen to T cells.

Original languageEnglish
Pages (from-to)3-6
Number of pages4
JournalCellular Immunology
Volume99
Issue number1
DOIs
StatePublished - Apr 15 1986

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