Biochemical alterations of membrane lipids associated with renal injury

A. R. Morrison; N. Pascoe; N. Tauk; D. Kennerly

Biochemical alterations of membrane lipids associated with renal injury

A. R. Morrison, N. Pascoe, N. Tauk, D. Kennerly

Research output: Contribution to journal › Article › peer-review

Abstract

Ureteral obstruction and partial renal vasoconstriction are associated with increased prostaglandin biosynthesis and arachidonate release from cellular phospholipids. HgCl₂-induced renal injury was associated with changes in respiratory control of mitochondria with loss of acceptor control and with marked morphological changes seen ultrastructurally. The mitochondrial lipids showed losses of 29 and 46%, respectively, of phosphatidylethanolamine and cardiolipin. These biochemical changes may be the markers of the functional and ultrastructural derangements seen in toxic renal injury.

Original language	English
Pages (from-to)	2811-2814
Number of pages	4
Journal	Federation proceedings
Volume	43
Issue number	13
State	Published - Jan 1 1984

Cite this

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abstract = "Ureteral obstruction and partial renal vasoconstriction are associated with increased prostaglandin biosynthesis and arachidonate release from cellular phospholipids. HgCl2-induced renal injury was associated with changes in respiratory control of mitochondria with loss of acceptor control and with marked morphological changes seen ultrastructurally. The mitochondrial lipids showed losses of 29 and 46%, respectively, of phosphatidylethanolamine and cardiolipin. These biochemical changes may be the markers of the functional and ultrastructural derangements seen in toxic renal injury.",

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N2 - Ureteral obstruction and partial renal vasoconstriction are associated with increased prostaglandin biosynthesis and arachidonate release from cellular phospholipids. HgCl2-induced renal injury was associated with changes in respiratory control of mitochondria with loss of acceptor control and with marked morphological changes seen ultrastructurally. The mitochondrial lipids showed losses of 29 and 46%, respectively, of phosphatidylethanolamine and cardiolipin. These biochemical changes may be the markers of the functional and ultrastructural derangements seen in toxic renal injury.

AB - Ureteral obstruction and partial renal vasoconstriction are associated with increased prostaglandin biosynthesis and arachidonate release from cellular phospholipids. HgCl2-induced renal injury was associated with changes in respiratory control of mitochondria with loss of acceptor control and with marked morphological changes seen ultrastructurally. The mitochondrial lipids showed losses of 29 and 46%, respectively, of phosphatidylethanolamine and cardiolipin. These biochemical changes may be the markers of the functional and ultrastructural derangements seen in toxic renal injury.

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Biochemical alterations of membrane lipids associated with renal injury

Abstract

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