Bioavailable vitamin D in chronic kidney disease

Alex J. Brown; Daniel W. Coyne

doi:10.1038/ki.2012.135

Bioavailable vitamin D in chronic kidney disease

Alex J. Brown
, Daniel W. Coyne

Research output: Contribution to journal › Comment/debate

34 Scopus citations

Abstract

Most of the major vitamin D metabolites 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D circulates in a tightly bound state to vitamin D-binding protein (DBP), rendering this fraction unavailable for biological action. A smaller fraction, loosely bound to albumin or circulating freely, is bioavailable, and hence bioactive. This Commentary discusses the free hormone hypothesis and the role of DBP in vitamin D metabolism.

Original language	English
Pages (from-to)	5-7
Number of pages	3
Journal	Kidney International
Volume	82
Issue number	1
DOIs	https://doi.org/10.1038/ki.2012.135
State	Published - Jul 1 2012

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10.1038/ki.2012.135

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title = "Bioavailable vitamin D in chronic kidney disease",

abstract = "Most of the major vitamin D metabolites 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D circulates in a tightly bound state to vitamin D-binding protein (DBP), rendering this fraction unavailable for biological action. A smaller fraction, loosely bound to albumin or circulating freely, is bioavailable, and hence bioactive. This Commentary discusses the free hormone hypothesis and the role of DBP in vitamin D metabolism.",

author = "Brown, \{Alex J.\} and Coyne, \{Daniel W.\}",

note = "Funding Information: DWC is a consultant and speaker for Abbott. AJB has research grants from Abbott and Chugai Pharmaceuticals. ",

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AU - Brown, Alex J.

AU - Coyne, Daniel W.

N1 - Funding Information: DWC is a consultant and speaker for Abbott. AJB has research grants from Abbott and Chugai Pharmaceuticals.

PY - 2012/7/1

Y1 - 2012/7/1

N2 - Most of the major vitamin D metabolites 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D circulates in a tightly bound state to vitamin D-binding protein (DBP), rendering this fraction unavailable for biological action. A smaller fraction, loosely bound to albumin or circulating freely, is bioavailable, and hence bioactive. This Commentary discusses the free hormone hypothesis and the role of DBP in vitamin D metabolism.

AB - Most of the major vitamin D metabolites 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D circulates in a tightly bound state to vitamin D-binding protein (DBP), rendering this fraction unavailable for biological action. A smaller fraction, loosely bound to albumin or circulating freely, is bioavailable, and hence bioactive. This Commentary discusses the free hormone hypothesis and the role of DBP in vitamin D metabolism.

UR - https://www.scopus.com/pages/publications/84862495659

U2 - 10.1038/ki.2012.135

DO - 10.1038/ki.2012.135

M3 - Comment/debate

C2 - 22699377

AN - SCOPUS:84862495659

SN - 0085-2538

VL - 82

SP - 5

EP - 7

JO - Kidney International

JF - Kidney International

IS - 1

ER -

Bioavailable vitamin D in chronic kidney disease

Abstract

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