Bioavailable vitamin D in chronic kidney disease

Alex J. Brown, Daniel W. Coyne

Research output: Contribution to journalComment/debate

27 Scopus citations


Most of the major vitamin D metabolites 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D circulates in a tightly bound state to vitamin D-binding protein (DBP), rendering this fraction unavailable for biological action. A smaller fraction, loosely bound to albumin or circulating freely, is bioavailable, and hence bioactive. This Commentary discusses the free hormone hypothesis and the role of DBP in vitamin D metabolism.

Original languageEnglish
Pages (from-to)5-7
Number of pages3
JournalKidney International
Issue number1
StatePublished - Jul 1 2012

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