Bioavailability of single-dose SUBA-itraconazole compared to conventional itraconazole under fasted and fed conditions

Adriana M. Rauseo, Patrick Mazi, Phoebe Lewis, Bruce Burnett, Stuart Mudge, Andrej Spec

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Conventional itraconazole (C-ITZ) suffers from absorption variability. SUBA-itraconazole (S-ITZ) is more bioavailable than C-ITZ at steady state in a fed condition, but there are no data comparing the two under a fasted state. An open-label, single-dose, randomized, bioequivalence study was performed comparing S-ITZ to C-ITZ capsules under fasted and fed conditions in healthy adults measuring itraconazole and hydroxyitraconazole plasma levels. This study demonstrated less variability of S-ITZ compared to C-ITZ capsules under fasted conditions.

Original languageEnglish
Article numbere00134
JournalAntimicrobial agents and chemotherapy
Volume65
Issue number8
DOIs
StatePublished - Aug 2021

Keywords

  • Bioavailability
  • Endemic mycoses
  • Itraconazole
  • Pharmacokinetics

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