Binding of the products of prothrombin activation to human platelets

D. M. Tollefsen, C. M. Jackson, P. W. Majerus

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Binding of prothrombin and activation intermediates 1 and 2 to human platelets was tested with 125I-labeled protein preparations. None of these precursors of thrombin bound to platelets under conditions in which high affinity binding of thrombin was observed, nor did they cause platelet aggregation or serotonin release. The molecular conformation required for binding to platelets as well as for induction of platelet aggregation and release is present, therefore, only after the final step in prothrombin activation.

Original languageEnglish
Pages (from-to)241-245
Number of pages5
JournalJournal of Clinical Investigation
Volume56
Issue number1
DOIs
StatePublished - 1975

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