TY - JOUR
T1 - Big roles for Fat cadherins
AU - Blair, Seth
AU - McNeill, Helen
N1 - Publisher Copyright:
© 2017
PY - 2018/4
Y1 - 2018/4
N2 - To create an intricately patterned and reproducibly sized and shaped organ, many cellular processes must be tightly regulated. Cell elongation, migration, metabolism, proliferation rates, cell–cell adhesion, planar polarization and junctional contractions all must be coordinated in time and space. Remarkably, a pair of extremely large cell adhesion molecules called Fat (Ft) and Dachsous (Ds), acting largely as a ligand–receptor system, regulate, and likely coordinate, these many diverse processes. Here we describe recent exciting progress on how the Ds–Ft pathway controls these diverse processes, and highlight a few of the many questions remaining as to how these enormous cell adhesion molecules regulate development.
AB - To create an intricately patterned and reproducibly sized and shaped organ, many cellular processes must be tightly regulated. Cell elongation, migration, metabolism, proliferation rates, cell–cell adhesion, planar polarization and junctional contractions all must be coordinated in time and space. Remarkably, a pair of extremely large cell adhesion molecules called Fat (Ft) and Dachsous (Ds), acting largely as a ligand–receptor system, regulate, and likely coordinate, these many diverse processes. Here we describe recent exciting progress on how the Ds–Ft pathway controls these diverse processes, and highlight a few of the many questions remaining as to how these enormous cell adhesion molecules regulate development.
UR - http://www.scopus.com/inward/record.url?scp=85038261134&partnerID=8YFLogxK
U2 - 10.1016/j.ceb.2017.11.006
DO - 10.1016/j.ceb.2017.11.006
M3 - Review article
C2 - 29258012
AN - SCOPUS:85038261134
SN - 0955-0674
VL - 51
SP - 73
EP - 80
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
ER -