Bictegravir-Based Antiretroviral Therapy-Associated Accelerated Hyperglycemia and Diabetes Mellitus

Nathanial S. Nolan; Samantha Adamson; Dominic Reeds; Jane A. O'Halloran

doi:10.1093/ofid/ofab077

Bictegravir-Based Antiretroviral Therapy-Associated Accelerated Hyperglycemia and Diabetes Mellitus

Nathanial S. Nolan
, Samantha Adamson
, Dominic Reeds
, Jane A. O'Halloran

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Integrase strand transfer inhibitor (INSTI)-based antiretroviral therapy (ART) is first line for treatment of people with human immunodeficiency virus (PWH). Emerging data suggest the possibility of adverse metabolic effects of these medications. We describe 3 cases in which PWH developed hyperglycemia and ketoacidosis within months of being switched to bictegravir-based ART.

Original language	English
Article number	ofab077
Journal	Open Forum Infectious Diseases
Volume	8
Issue number	5
DOIs	https://doi.org/10.1093/ofid/ofab077
State	Published - May 1 2021

Keywords

HIV
bictegravir
diabetes
hyperglycemia
integrase strand transfer inhibitors

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title = "Bictegravir-Based Antiretroviral Therapy-Associated Accelerated Hyperglycemia and Diabetes Mellitus",

abstract = "Integrase strand transfer inhibitor (INSTI)-based antiretroviral therapy (ART) is first line for treatment of people with human immunodeficiency virus (PWH). Emerging data suggest the possibility of adverse metabolic effects of these medications. We describe 3 cases in which PWH developed hyperglycemia and ketoacidosis within months of being switched to bictegravir-based ART.",

keywords = "HIV, bictegravir, diabetes, hyperglycemia, integrase strand transfer inhibitors",

author = "Nolan, \{Nathanial S.\} and Samantha Adamson and Dominic Reeds and O'Halloran, \{Jane A.\}",

note = "Publisher Copyright: {\textcopyright} 2021 The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America.",

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AU - Nolan, Nathanial S.

AU - Adamson, Samantha

AU - Reeds, Dominic

AU - O'Halloran, Jane A.

PY - 2021/5/1

Y1 - 2021/5/1

N2 - Integrase strand transfer inhibitor (INSTI)-based antiretroviral therapy (ART) is first line for treatment of people with human immunodeficiency virus (PWH). Emerging data suggest the possibility of adverse metabolic effects of these medications. We describe 3 cases in which PWH developed hyperglycemia and ketoacidosis within months of being switched to bictegravir-based ART.

AB - Integrase strand transfer inhibitor (INSTI)-based antiretroviral therapy (ART) is first line for treatment of people with human immunodeficiency virus (PWH). Emerging data suggest the possibility of adverse metabolic effects of these medications. We describe 3 cases in which PWH developed hyperglycemia and ketoacidosis within months of being switched to bictegravir-based ART.

KW - HIV

KW - bictegravir

KW - diabetes

KW - hyperglycemia

KW - integrase strand transfer inhibitors

UR - https://www.scopus.com/pages/publications/85118883853

U2 - 10.1093/ofid/ofab077

DO - 10.1093/ofid/ofab077

M3 - Article

C2 - 33981777

AN - SCOPUS:85118883853

SN - 2328-8957

VL - 8

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

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M1 - ofab077

ER -

Bictegravir-Based Antiretroviral Therapy-Associated Accelerated Hyperglycemia and Diabetes Mellitus

Abstract

Keywords

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