Bicarbonate-buffered Lidocaine-epinephirine-hyaluronidase for Eyelid Anesthesia

Scott G. Eccarius, Mae E. Gordon, Joseph J. Parelman

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


A double-masked, randomized clinical trial was conducted to determine if subcutaneous eyelid injections of a bicarbonate-buffered lidocaine-epinephrine-hyaluronidase mixture were less painful than unbuffered injections. Twenty-one patients received both buffered (pH = 7.4) and unbuffered (pH = 4.6) injections. After each injection, patients recorded pain on a scale of 0, “no pain,” to 10, “severe pain.” Mean pain score for buffered injections was 2.0 versus 4.1 for unbuffered injections (P = 0.0003). Seventeen (81%) of 21 patients ranked the buffered injection less painful. Use of a bicarbonate-buffered lidocaine-epinephrine-hyaluronidase mixture is effective in making ophthalmic anesthesia less painful.

Original languageEnglish
Pages (from-to)1499-1501
Number of pages3
Issue number11
StatePublished - 1990


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