TY - JOUR
T1 - Biaryl cannabinoid mimetics-Synthesis and structure-activity relationship
AU - Worm, Karin
AU - Zhou, Q. Jean
AU - Stabley, Gabriel J.
AU - DeHaven, Robert N.
AU - Dolle, Roland E.
PY - 2007/7/1
Y1 - 2007/7/1
N2 - Synthesis, in vitro biological evaluation, and structure-activity relationships of a biaryl cannabinoid mimetic 2 are reported. Variations in the substitution pattern yielded a number of agonists with low nanomolar affinity. Replacing the phenol group by a methyl morpholino acetate group led to compound 28, a 500-fold selective CB2 receptor agonist.
AB - Synthesis, in vitro biological evaluation, and structure-activity relationships of a biaryl cannabinoid mimetic 2 are reported. Variations in the substitution pattern yielded a number of agonists with low nanomolar affinity. Replacing the phenol group by a methyl morpholino acetate group led to compound 28, a 500-fold selective CB2 receptor agonist.
KW - Cannabinoid CB receptors
KW - Cannabinoid CB receptors
KW - Structure-activity relationships
UR - http://www.scopus.com/inward/record.url?scp=34250179461&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2007.04.059
DO - 10.1016/j.bmcl.2007.04.059
M3 - Article
C2 - 17507224
AN - SCOPUS:34250179461
SN - 0960-894X
VL - 17
SP - 3652
EP - 3656
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 13
ER -