Beyond the gastrointestinal tract: The emerging and diverse tissue tropisms of astroviruses

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Astroviruses are single stranded, positive-sense RNA viruses that have been historically associated with diseases of the gastrointestinal tract of vertebrates, including humans. However, there is now a multitude of evidence demonstrating the capacity of these viruses to cause extrain-testinal diseases. The most striking causal relationship is neurological diseases in humans, cattle, pigs, and other mammals, caused by astrovirus infection. Astroviruses have also been associated with disseminated infections, localized disease of the liver or kidneys, and there is increasing evidence suggesting a potential tropism to the respiratory tract. This review will discuss the current understanding of the tissue tropisms for astroviruses and their emerging capacity to cause disease in multiple organ systems.

Original languageEnglish
Article number732
JournalViruses
Volume13
Issue number5
DOIs
StatePublished - May 2021

Keywords

  • Astroviruses
  • Encephalitis
  • Gastroenteritis
  • Hepatitis
  • Respiratory disease
  • Tropism

Fingerprint

Dive into the research topics of 'Beyond the gastrointestinal tract: The emerging and diverse tissue tropisms of astroviruses'. Together they form a unique fingerprint.

Cite this