Benzodiazepines are weak inhibitors of [3H]nitrobenzylthioinosine binding to adenosine uptake sites in brain

J. Patel, P. J. Marangos, P. Skolnick, S. M. Paul, A. M. Martino

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Saturable, specific, high affinity binding of the potent adenosine uptake inhibitor [3H]nitrobenzylthioinosine ([3H]NBI) to brain membranes has been demonstrated. In an effort to test the hypothesis that benzodiazepine action may be due to the inhibition of adenosine uptake, the inhibition of [3H]NBI binding by diazepam, clonazepam and chlordiazepoxide was tested. The benzodiazepines are very weak inhibitors of [3H]NBI binding, having IC50 values several orders of magnitude above their therapeutic levels.

Original languageEnglish
Pages (from-to)79-82
Number of pages4
JournalNeuroscience Letters
Volume29
Issue number1
DOIs
StatePublished - Mar 17 1982
Externally publishedYes

Keywords

  • adenosine uptake
  • benzodiazepine
  • binding sites
  • nitrobenzylthioinosine

Fingerprint Dive into the research topics of 'Benzodiazepines are weak inhibitors of [<sup>3</sup>H]nitrobenzylthioinosine binding to adenosine uptake sites in brain'. Together they form a unique fingerprint.

  • Cite this