Benzodiazepine-receptor mediated inhibition of isolation-induced aggression in mice

Phil Skolnick, George F. Reed, Steven M. Paul

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


The effects of a benzodiazepine receptor agonist (diazepam), antagonist (Ro 15-1788), and an "active" antagonist [inverse agonist] (3-carboethoxy-β-carboline) were examined in an isolation-induced model of aggression. Diazepam (4 mg/kg) and 3-carboethoxy-β-carboline (10 mg/kg), but not Ro 15-1788, significantly inhibited aggressive behavior in this model. Ro 15-1788 (10 mg/kg) reduced the anti-aggressive actions of both diazepam and 3-carboethoxy-β-carboline, while mice treated with a combination of diazepam and 3-carboethoxy-β-carboline had aggression scores increased to values not significantly different from vehicle treated mice. These findings suggest that both diazepam and 3-carboethoxy-β-carboline have anti-aggressive properties in the isolation-induced model of aggression which are mediated through CNS benzodiazepine receptors.

Original languageEnglish
Pages (from-to)17-20
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Issue number1
StatePublished - Jul 1985


  • 3-Carboethoxy-β-carboline
  • Aggression
  • Diazepam
  • Isolation
  • Ro 15-1788


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