Benzodiazepine receptor-mediated experimental "anxiety" in primates

Philip T. Ninan, Thomas M. Insel, Robert M. Cohen, James M. Cook, Phil Skolnick, Steven M. Paul

Research output: Contribution to journalArticlepeer-review

298 Scopus citations


The ethyl ester of β-carboline-3-carboxylic acid has a high affinity for benzodiazepine receptors in the brain. In the rhesus monkey this substance produces an acute behavioral syndrome characterized by dramatic elevations in heart rate, blood pressure, plasma cortisol, and catecholamines. The effects are blocked by benzodiazepines and the specific benzodiazepine receptor antagonist Ro 15-1788. The benzodiazepine receptor may consist of several subsites or functional domains that independently recognize agonists, antagonists, or "active" antagonists such as β-carboline-3-carboxylic acid ethyl ester. These results suggest that the benzodiazepine receptor is involved in both the affective and physiological manifestations of anxiety, and that the administration of β-carboline-3-carboxylic acid ethyl ester to monkeys may provide a reliable and reproducible animal model of human anxiety.

Original languageEnglish
Pages (from-to)1332-1334
Number of pages3
Issue number4579
StatePublished - 1982


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