Benefits of Optimizing Heart Failure Medication Dosage

Sandra Oliver-McNeil, Margaret Bowers, Shane J. LaRue, Justin Vader, Adam D. DeVore, Bradi B. Granger

Research output: Contribution to journalArticlepeer-review


Heart failure is the leading cause of hospitalizations and readmissions. Guideline-directed medical therapy is the cornerstone to improving outcomes, but less than 20% of patients with heart failure marked by reduced ejection fraction receive target doses. This report reviews the neurohormonal cascade that occurs in heart failure and the role of guideline-directed medical therapy based on the results of landmark trials. In addition, evidence-based strategies to up-titrate medications are described. Nurse practitioners are in an optimal situation to titrate guideline therapy with frequent follow-up and monitoring.

Original languageEnglish
Pages (from-to)498-503
Number of pages6
JournalJournal for Nurse Practitioners
Issue number7
StatePublished - Jul 1 2020


  • HFrEF
  • guideline-directed medical therapy (GDMT)
  • heart failure guidelines
  • postdischarge care transition


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