TY - JOUR
T1 - Benefits of Optimizing Heart Failure Medication Dosage
AU - Oliver-McNeil, Sandra
AU - Bowers, Margaret
AU - LaRue, Shane J.
AU - Vader, Justin
AU - DeVore, Adam D.
AU - Granger, Bradi B.
N1 - Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/7/1
Y1 - 2020/7/1
N2 - Heart failure is the leading cause of hospitalizations and readmissions. Guideline-directed medical therapy is the cornerstone to improving outcomes, but less than 20% of patients with heart failure marked by reduced ejection fraction receive target doses. This report reviews the neurohormonal cascade that occurs in heart failure and the role of guideline-directed medical therapy based on the results of landmark trials. In addition, evidence-based strategies to up-titrate medications are described. Nurse practitioners are in an optimal situation to titrate guideline therapy with frequent follow-up and monitoring.
AB - Heart failure is the leading cause of hospitalizations and readmissions. Guideline-directed medical therapy is the cornerstone to improving outcomes, but less than 20% of patients with heart failure marked by reduced ejection fraction receive target doses. This report reviews the neurohormonal cascade that occurs in heart failure and the role of guideline-directed medical therapy based on the results of landmark trials. In addition, evidence-based strategies to up-titrate medications are described. Nurse practitioners are in an optimal situation to titrate guideline therapy with frequent follow-up and monitoring.
KW - HFrEF
KW - guideline-directed medical therapy (GDMT)
KW - heart failure guidelines
KW - postdischarge care transition
UR - http://www.scopus.com/inward/record.url?scp=85084732017&partnerID=8YFLogxK
U2 - 10.1016/j.nurpra.2020.04.018
DO - 10.1016/j.nurpra.2020.04.018
M3 - Article
AN - SCOPUS:85084732017
SN - 1555-4155
VL - 16
SP - 498
EP - 503
JO - Journal for Nurse Practitioners
JF - Journal for Nurse Practitioners
IS - 7
ER -