Beneficial effects of donor-specific transfusions on long-term renal allograft function

C. B. Anderson, D. Brennan, C. Keller, J. Goss, S. Shenoy, K. Burton, G. Sicard, M. W. Flye

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


The induction of immunologic unresponsiveness to improve renal allograft survival was attempted in 163 patients by the pretransplant administration of donor-specific whole blood or buffy coat in conjunction with continuous Aza immunosuppression. All donor-recipient combinations were at least one- haplotype disparate, and 21 were two-haplotype disparate. Transient sensitization occurred in 2% and permanent sensitization in 7%. Over a 10- year period, the DST + Aza allograft survival rate is similar to the HLA- identical sibling transplants. The CMV sepsis rate was only 2%, and there were no lymphoproliferative neoplasms. The low rate of sensitization (7%) has permitted almost all patients to undergo eventual renal transplantation from the specific blood donor. This and the low rate of early rejection (3%) argues for a modification of the immunologic response.

Original languageEnglish
Pages (from-to)991-994
Number of pages4
JournalTransplantation Proceedings
Issue number1
StatePublished - 1995


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