@article{bdc3dfafd0a6482baa525138c35cd98d,
title = "Behavioral Signatures of a Developing Neural Code",
abstract = "During early life, neural codes must develop to appropriately transform sensory inputs into behavioral outputs. Here, we demonstrate a link between the maturity of neural coding in the visual brain and developmental changes in visually guided behavior. In zebrafish larvae, we show that visually driven hunting behavior improves from 4 to 15 days post-fertilization, becoming faster and more accurate. During the same period, population activity in parts of the optic tectum refines, improving decoding and information transmission for particular spatial positions. Remarkably, individual differences in decoding can predict each fish's hunting success. Together, these results help reveal how the neural codes required for a natural behavior emerge during development.",
keywords = "behavioral development, calcium imaging, individual differences, mutual information, neural assemblies, neural decoding, neural development, optic tectum, prey capture, zebrafish",
author = "Lilach Avitan and Zac Pujic and Jan M{\"o}lter and Michael McCullough and Shuyu Zhu and Biao Sun and Myhre, {Ann Elin} and Goodhill, {Geoffrey J.}",
note = "Funding Information: We gratefully acknowledge funding from Australian Research Council grants DP170102263 and DP180100636. Imaging was performed at the Queensland Brain Institute's Advanced Microscopy Facility using a Zeiss LSM 710 2-photon microscope, generously supported by the Australian Government through the ARC LIEF grant LE130100078. Conceptualization, L.A. and G.J.G.; Methodology, L.A. Z.P. S.Z. and G.J.G.; Software, L.A. J.M. and M.M.; Formal Analysis, L.A. J.M. and M.M.; Investigation, L.A. Z.P. J.M. M.M. S.Z. B.S. and A.M.; Writing ? Original Draft, L.A. J.M. and G.J.G.; Writing ? Review & Editing, L.A. Z.P. J.M. M.M. S.Z. B.S. A.M. and G.J.G.; Supervision, G.J.G.; Funding Acquisition, G.J.G. The authors declare no competing interests. Funding Information: We gratefully acknowledge funding from Australian Research Council grants DP170102263 and DP180100636 . Imaging was performed at the Queensland Brain Institute{\textquoteright}s Advanced Microscopy Facility using a Zeiss LSM 710 2-photon microscope, generously supported by the Australian Government through the ARC LIEF grant LE130100078 . Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = sep,
day = "7",
doi = "10.1016/j.cub.2020.06.040",
language = "English",
volume = "30",
pages = "3352--3363.e5",
journal = "Current Biology",
issn = "0960-9822",
number = "17",
}