TY - JOUR
T1 - Behavioral inhibition corresponds to white matter fiber bundle integrity in older adults
AU - Garcia-Egan, Paola M.
AU - Preston-Campbell, Rebecca N.
AU - Salminen, Lauren E.
AU - Heaps-Woodruff, Jodi M.
AU - Balla, Lila
AU - Cabeen, Ryan P.
AU - Laidlaw, David H.
AU - Conturo, Thomas E.
AU - Paul, Robert H.
N1 - Funding Information:
Funding Supported by National Institutes of Health/National Institute of Neurological Disorders and Stroke grant number R01 NS052470 and R01 NS039538, National Institutes of Health/National Institute of Mental Health grant R21 MH090494.
Publisher Copyright:
© 2019, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Little is known about the contribution of white matter integrity to inhibitory cognitive control, particularly in healthy aging. The present study examines the correspondence between white matter fiber bundle length and behavioral inhibition in 37 community-dwelling older adults (aged 51–78 years). Participants underwent neuroimaging with 3 Tesla MRI, and completed a behavioral test of inhibition (i.e., Go/NoGo task). Quantitative tractography derived from diffusion tensor imaging (qtDTI) was used to measure white matter fiber bundle lengths (FBLs) in tracts known to innervate frontal brain regions, including the anterior corpus callosum (AntCC), the cingulate gyrus segment of the cingulum bundle (CING), uncinate fasciculus (UNC), and the superior longitudinal fasciculus (SLF). Performance on the Go/NoGo task was measured by the number of commission errors standardized to reaction time. Hierarchical regression models revealed that shorter FBLs in the CING (p < 0.05) and the bilateral UNC (p < 0.01) were associated with lower inhibitory performance after adjusting for multiple comparisons, supporting a disconnection model of response inhibition in older adults. Prospective longitudinal studies are needed to examine the evolution of inhibitory errors in older adult populations and potential for therapeutic intervention.
AB - Little is known about the contribution of white matter integrity to inhibitory cognitive control, particularly in healthy aging. The present study examines the correspondence between white matter fiber bundle length and behavioral inhibition in 37 community-dwelling older adults (aged 51–78 years). Participants underwent neuroimaging with 3 Tesla MRI, and completed a behavioral test of inhibition (i.e., Go/NoGo task). Quantitative tractography derived from diffusion tensor imaging (qtDTI) was used to measure white matter fiber bundle lengths (FBLs) in tracts known to innervate frontal brain regions, including the anterior corpus callosum (AntCC), the cingulate gyrus segment of the cingulum bundle (CING), uncinate fasciculus (UNC), and the superior longitudinal fasciculus (SLF). Performance on the Go/NoGo task was measured by the number of commission errors standardized to reaction time. Hierarchical regression models revealed that shorter FBLs in the CING (p < 0.05) and the bilateral UNC (p < 0.01) were associated with lower inhibitory performance after adjusting for multiple comparisons, supporting a disconnection model of response inhibition in older adults. Prospective longitudinal studies are needed to examine the evolution of inhibitory errors in older adult populations and potential for therapeutic intervention.
KW - Aging
KW - Go/NoGo
KW - Inhibition
KW - MRI fiber bundle length
KW - Quantitative diffusion tensor imaging
KW - White matter
UR - http://www.scopus.com/inward/record.url?scp=85067881969&partnerID=8YFLogxK
U2 - 10.1007/s11682-019-00144-1
DO - 10.1007/s11682-019-00144-1
M3 - Article
C2 - 31209835
AN - SCOPUS:85067881969
VL - 13
SP - 1602
EP - 1611
JO - Brain Imaging and Behavior
JF - Brain Imaging and Behavior
SN - 1931-7557
IS - 6
ER -