TY - JOUR
T1 - Behavioral analyses of animal models of intellectual and developmental disabilities
AU - Crawley, Jacqueline N.
AU - Fagiolini, Michela
AU - Harrison, Fiona E.
AU - Samaco, Rodney
AU - Wozniak, David F.
AU - Robinson, Michael B.
N1 - Funding Information:
The authors of this editorial were partially supported by their respective Intellectual and Developmental Disabilities Research Centers that are funded by the Eunice Kennedy Shriver National Institutes of Health , including, UC Davis ( U54 HD079125 ), Boston Children’s Hospital ( U54 HD090255 ), Vanderbilt University ( U54 HD083211 ), Baylor College of Medicine ( U54 HD083092 ), Washington University ( U54 HD087011 ) and Children’s Hospital of Philadelphia/University of Pennsylvania ( U54 HD0086984 ). The content of this editorial is solely the responsibility of the authors and does not necessarily represent the official view of the National Institute of Health.
Funding Information:
The authors of this editorial were partially supported by their respective Intellectual and Developmental Disabilities Research Centers that are funded by the Eunice Kennedy Shriver National Institutes of Health, including, UC Davis (U54 HD079125), Boston Children's Hospital (U54 HD090255), Vanderbilt University (U54 HD083211), Baylor College of Medicine (U54 HD083092), Washington University (U54 HD087011) and Children's Hospital of Philadelphia/University of Pennsylvania (U54 HD0086984). The content of this editorial is solely the responsibility of the authors and does not necessarily represent the official view of the National Institute of Health.
Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/11
Y1 - 2019/11
N2 - Intellectual and developmental disabilities (IDDs) are a common group of disorders that frequently share overlapping symptoms, including cognitive deficits, altered attention, seizures, impaired social interactions, and anxiety. The causes of these disorders are varied ranging from early prenatal/postnatal insults to genetic variants that either cause or are associated with an increased likelihood of an IDD. As many of the symptoms observed in individuals with IDDs are a manifestation of altered nervous system function resulting in altered behaviors, it should not be surprising that the field is very dependent upon in vivo model systems. This special issue of Neurobiology of Learning and Memory is focused on the methods and approaches that are being used to model and understand these disorders in mammals. While surveys by the Pew Foundation continue to find a high degree of confidence/trust in scientists by the public, several recent studies have documented issues with reproducibility in scientific publications. This special issue includes both primary research articles and review articles in which careful attention has been made to transparently report methods and use rigorous approaches to ensure reproducibility. Although there have been and will continue to be remarkable advances for treatment of subset of IDDs, it is clear that this field is still in its early stages. There is no doubt that the strategies being used to model IDDs will continue to evolve. We hope this special issue will support this evolution so that we can maintain the trust of the public and elected officials, and continue developing evidence-based approaches to new therapeutics.
AB - Intellectual and developmental disabilities (IDDs) are a common group of disorders that frequently share overlapping symptoms, including cognitive deficits, altered attention, seizures, impaired social interactions, and anxiety. The causes of these disorders are varied ranging from early prenatal/postnatal insults to genetic variants that either cause or are associated with an increased likelihood of an IDD. As many of the symptoms observed in individuals with IDDs are a manifestation of altered nervous system function resulting in altered behaviors, it should not be surprising that the field is very dependent upon in vivo model systems. This special issue of Neurobiology of Learning and Memory is focused on the methods and approaches that are being used to model and understand these disorders in mammals. While surveys by the Pew Foundation continue to find a high degree of confidence/trust in scientists by the public, several recent studies have documented issues with reproducibility in scientific publications. This special issue includes both primary research articles and review articles in which careful attention has been made to transparently report methods and use rigorous approaches to ensure reproducibility. Although there have been and will continue to be remarkable advances for treatment of subset of IDDs, it is clear that this field is still in its early stages. There is no doubt that the strategies being used to model IDDs will continue to evolve. We hope this special issue will support this evolution so that we can maintain the trust of the public and elected officials, and continue developing evidence-based approaches to new therapeutics.
UR - http://www.scopus.com/inward/record.url?scp=85072632735&partnerID=8YFLogxK
U2 - 10.1016/j.nlm.2019.107087
DO - 10.1016/j.nlm.2019.107087
M3 - Editorial
C2 - 31499164
AN - SCOPUS:85072632735
SN - 1074-7427
VL - 165
JO - Neurobiology of Learning and Memory
JF - Neurobiology of Learning and Memory
M1 - 107087
ER -