Behavior of Parasite-Specific Effector CD8+ T Cells in the Brain and Visualization of a Kinesis-Associated System of Reticular Fibers

Emma H. Wilson, Tajie H. Harris, Paulus Mrass, Beena John, Elia D. Tait, Gregory F. Wu, Marion Pepper, E. John Wherry, Florence Dzierzinski, David Roos, Philip G. Haydon, Terri M. Laufer, Wolfgang Weninger, Christopher A. Hunter

Research output: Contribution to journalArticlepeer-review

130 Scopus citations


To understand lymphocyte behavior in the brain, we used two-photon microscopy to visualize effector CD8+ T cells during toxoplasmic encephalitis. These cells displayed multiple behaviors with two distinct populations of cells apparent: one with a constrained pattern of migration and one with a highly migratory subset. The proportion of these populations varied over time associated with changes in antigen availability as well as T cell expression of the inhibitory receptor PD1. Unexpectedly, the movement of infiltrating cells was closely associated with an infection-induced reticular system of fibers. This observation suggests that, whereas in other tissues pre-existing scaffolds exist that guide lymphocyte migration, in the brain specialized structures are induced by inflammation that guide migration of T cells in this immune-privileged environment.

Original languageEnglish
Pages (from-to)300-311
Number of pages12
Issue number2
StatePublished - Feb 20 2009
Externally publishedYes



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