Bedside optical imaging of occipital resting-state functional connectivity in neonates

Brian R. White, Steve M. Liao, Silvina L. Ferradal, Terrie E. Inder, Joseph P. Culver

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

Resting-state networks derived from temporal correlations of spontaneous hemodynamic fluctuations have been extensively used to elucidate the functional organization of the brain in adults and infants. We have previously developed functional connectivity diffuse optical tomography methods in adults, and we now apply these techniques to study functional connectivity in newborn infants at the bedside. We present functional connectivity maps in the occipital cortices obtained from healthy term-born infants and premature infants, including one infant with an occipital stroke. Our results suggest that functional connectivity diffuse optical tomography has potential as a valuable clinical tool for the early detection of functional deficits and for providing prognostic information on future development.

Original languageEnglish
Pages (from-to)2529-2538
Number of pages10
JournalNeuroImage
Volume59
Issue number3
DOIs
StatePublished - Feb 1 2012

Keywords

  • Functional connectivity
  • Neonates
  • Optical tomography
  • Prematurity
  • Resting state

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