@article{3e2c9008cb2c4226bf289c6e3075c9f5,
title = "Battery-free, fully implantable optofluidic cuff system for wireless optogenetic and pharmacological neuromodulation of peripheral nerves",
abstract = "Studies of the peripheral nervous system rely on controlled manipulation of neuronal function with pharmacologic and/or optogenetic techniques. Traditional hardware for these purposes can cause notable damage to fragile nerve tissues, create irritation at the biotic/abiotic interface, and alter the natural behaviors of animals. Here, we present a wireless, battery-free device that integrates a microscale inorganic light-emitting diode and an ultralow-power microfluidic system with an electrochemical pumping mechanism in a soft platform that can be mounted onto target peripheral nerves for programmed delivery of light and/or pharmacological agents in freely moving animals. Biocompliant designs lead to minimal effects on overall nerve health and function, even with chronic use in vivo. The small size and light weight construction allow for deployment as fully implantable devices in mice. These features create opportunities for studies of the peripheral nervous system outside of the scope of those possible with existing technologies.",
author = "Yi Zhang and Mickle, {Aaron D.} and Philipp Gutruf and McIlvried, {Lisa A.} and Hexia Guo and Yixin Wu and Golden, {Judith P.} and Yeguang Xue and Grajales-Reyes, {Jose G.} and Xueju Wang and Siddharth Krishnan and Yiwen Xie and Dongsheng Peng and Su, {Chun Ju} and Fengyi Zhang and Reeder, {Jonathan T.} and Vogt, {Sherri K.} and Yonggang Huang and Rogers, {John A.} and Gereau, {Robert W.}",
note = "Funding Information: We would like to thank J. Sinn-Hanlon of the Design Group at VetMed, University of Illinois at Urbana-Champaign for the illustrations. This work used the Northwestern University Micro/Nano Fabrication Facility (NUFAB), which is partially supported by Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource (NSF ECCS-1542205). This work made use of the MatCI Facility, which receives support from the MRSEC Program (NSF DMR-1720139) of the Materials Research Center at Northwestern University This work was funded by an NIH Director{\textquoteright}s Transformative Research Award TR01 NS081707 (to R.W.G. and J.A.R.), NIH SPARC Award via the NIBIB of the NIH award U18EB021793 (to R.W.G. and J.A.R.), R01 NS42595 (to R.W.G.), NIMH of the NIH under Award Number R41MH116525, NRSA F32 DK115122 (to A.D.M.), the McDonnell Center for Cellular and Molecular Neurobiology Postdoctoral Fellowship (to A.D.M.), T32 DA007261 (to L.A.M.), the Medical Scientist Training Program (MSTP) Grant T32 GM07200 and NINDS NRSA F31 NS103472 (to J.G.G.-R.), and the University of Missouri-Columbia start-up fund (to Y.Z.). Publisher Copyright: Copyright {\textcopyright} 2019 The Authors.",
year = "2019",
doi = "10.1126/sciadv.aaw5296",
language = "English",
volume = "5",
journal = "Science Advances",
issn = "2375-2548",
number = "7",
}