This chapter will serve as a brief review of immunology for oncologists. No single chapter can fully describe the complexity of the immune system and so the goal here will be to simply serve as a refresher. Innate and adaptive immunity will be concisely reviewed, with a brief description of the cells of each system. Focus will then be paid to the how T cells are activated and function. Finally, basic principles of T cell-mediated immunity to tumors will be presented. These foundational concepts will be useful for understanding later chapters which largely deal with the purposeful engineering of immune cells for adoptive cellular therapies. An attempt has been made to highlight recent review articles for further reading, with an emphasis on those that involve tumor immunology.

Original languageEnglish
Title of host publicationCancer Drug Discovery and Development
PublisherHumana Press Inc.
Number of pages13
StatePublished - 2022

Publication series

NameCancer Drug Discovery and Development
ISSN (Print)2196-9906
ISSN (Electronic)2196-9914


  • Adaptive immunity
  • Antigen presenting cells (APCs)
  • B cell receptor (BCR)
  • B cells
  • CD4+ cells
  • CD8+ cells
  • Cytotoxic T lymphocytes (CTLs)
  • Dendritic cells (DCs)
  • Innate immunity
  • Innate lymphoid cells (ILCs)
  • Major histocompatibility (MHC) class I and class II molecules
  • Mucosal-associated invariant T (MAIT) cells
  • Myeloid-derived suppressor cells (MDSCs)
  • Natural killer (NK)
  • Natural killer T (NKT) cells
  • Pathogen recognition receptors (PRRs)
  • Pathogen-associated molecular patterns (PAMPs)
  • T cell receptor (TCR)
  • T cells
  • T follicular helper (Tfh)
  • T helper (Th1, Th2, Th17)
  • T regulatory cells (Treg)
  • Toll-like receptors (TLRs)
  • Tumor microenvironment (TME)
  • γδ T cells


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