TY - JOUR
T1 - Basic mechanisms of left ventricular remodeling
T2 - the contribution of wall stress.
AU - Mann, Douglas L.
N1 - Funding Information:
Supported, in part, by research funds from the N.I.H. (P50 HL-O6H and RO1 HL58081-01, RO1 HL61543-01, HL-42250-10/10).
PY - 2004/12
Y1 - 2004/12
N2 - Heart failure may be viewed as a progressive disorder that is impelled, at least in part, by progressive left ventricular (LV) remodeling. In the present discussion we will review the role of LV remodeling in the pathogenesis of heart failure, with a focus on the contribution that increased wall stress plays in the development and progression of LV remodeling. The clinical implication of this review is that existing neurohormonal strategies may not completely prevent disease progression in the failing heart, and that adjunctive strategies that are designed to specifically prevent or attenuate LV remodeling may play an important role in the clinical treatment of heart failure.
AB - Heart failure may be viewed as a progressive disorder that is impelled, at least in part, by progressive left ventricular (LV) remodeling. In the present discussion we will review the role of LV remodeling in the pathogenesis of heart failure, with a focus on the contribution that increased wall stress plays in the development and progression of LV remodeling. The clinical implication of this review is that existing neurohormonal strategies may not completely prevent disease progression in the failing heart, and that adjunctive strategies that are designed to specifically prevent or attenuate LV remodeling may play an important role in the clinical treatment of heart failure.
UR - http://www.scopus.com/inward/record.url?scp=18444411007&partnerID=8YFLogxK
U2 - 10.1016/j.cardfail.2004.09.008
DO - 10.1016/j.cardfail.2004.09.008
M3 - Review article
C2 - 15803551
AN - SCOPUS:18444411007
SN - 1071-9164
VL - 10
SP - S202-206
JO - Journal of cardiac failure
JF - Journal of cardiac failure
IS - 6 Suppl
ER -