Baseline test-retest findings of corneal scarring in the clek study

J. T. Barrl, G. E. Piercel, T. B. Edrington, K. Zadnikt, M. O. Gordon

Research output: Contribution to journalArticlepeer-review


Purpose: The Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study is a three-year observational study for which we developed a photodocumentation and reading procedure for corneal scarring. We evaluated the test-retest reproducibility of corneal scarring as recorded by clinician examiners in the 15 CLEK clinics, for readers in the CLEK. Photography Reading Center (CPRC) and between examiners and readers. Method: Corneal opacification was documented at baseline and at a repeat visit in a 10% random sample using standardized examination and photographic procedures. The examiners and the masked readers categorized the corneas as definitely no scar, probably no scar, probably scarred or definitely scarred. Scarring was defined as "present" if classified as probably scarred or definitely scarred. Results: We report on the agreement on corneal scarring between examiners (Kappa = 0.84) and between readers (Kappa = 0.74), and between examiners and readers. Reader Scar Present Reader Scar Absent Examiner Scar Present 179 58 Examiner Scar Absent 17 379 Kappa - 0.65; Specificity = 0.96; Sensitivity = 0.75 Conclusion: We find good agreement between clinician examiners and masked photograph readers and excellent reproducibility of results by both examiners and photograph readers for presence and absence of corneal scarring.

Original languageEnglish
Pages (from-to)S132
JournalInvestigative Ophthalmology and Visual Science
Issue number4
StatePublished - Dec 1 1997


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