TY - JOUR
T1 - Baseline Quality-of-Life of Caregivers of Patients With Heart Failure Prior to Advanced Therapies
T2 - Findings From the Sustaining Quality of Life of the Aged: Transplant or Mechanical Support (SUSTAIN-IT) Study
AU - PETTY, M. G.
AU - WU, T.
AU - ANDREI, A. C.
AU - BALDRIDGE, A.
AU - WARZECHA, A.
AU - KAO, A.
AU - SPERTUS, J.
AU - HSICH, E.
AU - DEW, M. A.
AU - PHAM, D.
AU - YANCY, C.
AU - HARTUPEE, J.
AU - COTTS, W.
AU - PAMBOUKIAN, S. V.
AU - PAGANI, F.
AU - LAMPERT, B.
AU - JOHNSON, M.
AU - MURRAY, M.
AU - TEKEDA, K.
AU - YUZEFPOLSKAYA, M.
AU - SILVESTRY, S.
AU - KIRKLIN, J. K.
AU - GRADY, K. L.
N1 - Funding Information:
This work was sponsored by the National Institutes of Health, National Institute on Aging (NIA), Sustain ing qual it y of life of the aged: Heart transplant or mechanical circulatory support? (SUSTAIN-IT) (R01AG047416, PI: Grady KL).
Funding Information:
The authors are grateful to the patients and their caregivers for their participation and to the research teams at each of our participating centers for their support in making this research possible. This work was sponsored by the National Institutes of Health, National Institute on Aging (NIA), Sustaining quality of life of the aged: Heart transplant or mechanical circulatory support? (SUSTAIN-IT) (R01AG047416, PI: Grady KL).
Publisher Copyright:
© 2022 Elsevier Inc.
PY - 2022/7
Y1 - 2022/7
N2 - Background: We compared health-related quality of life (HRQOL), depressive symptoms, anxiety, and burden in caregivers of older patients with heart failure based on the intended therapy goal of the patient: awaiting heart transplantation (HT) with or without mechanical circulatory support (MCS) or prior to long-term MCS; and we identified factors associated with HRQOL. Methods: Caregivers (n = 281) recruited from 13 HT and MCS programs in the United States completed measures of HRQOL (EQ-5D-3L), depressive symptoms (PHQ-8), anxiety (STAI-state), and burden (Oberst Caregiving Burden Scale). Analyses included ANOVA, Kruskal-Wallis tests, χ2 tests, and linear regression. Results: The majority of caregivers were female, white spouses with ≤ 2 comorbidities, median [Q1,Q3] age = 62 [57.8, 67.0] years. Caregivers (HT with MCS = 87, HT without MCS = 98, long-term MCS = 96) reported similarly high baseline HRQOL (EQ-5D-3L visual analog scale median score = 90; P = 0.67 for all groups) and low levels of depressive symptoms. STAI-state median scores were higher in the long-term MCS group vs the HT groups with and without MCS, (38 vs 32 vs 31; P < 0.001), respectively. Burden (task: time spent/difficulty) differed significantly among groups. Caregiver factors (number of comorbidities, diabetes and higher anxiety levels) were significantly associated with worse caregiver HRQOL, R2 = 26%. Conclusions: Recognizing caregiver-specific factors, including comorbidities and anxiety, associated with the HRQOL of caregivers of these older patients with advanced HF may guide support strategies.
AB - Background: We compared health-related quality of life (HRQOL), depressive symptoms, anxiety, and burden in caregivers of older patients with heart failure based on the intended therapy goal of the patient: awaiting heart transplantation (HT) with or without mechanical circulatory support (MCS) or prior to long-term MCS; and we identified factors associated with HRQOL. Methods: Caregivers (n = 281) recruited from 13 HT and MCS programs in the United States completed measures of HRQOL (EQ-5D-3L), depressive symptoms (PHQ-8), anxiety (STAI-state), and burden (Oberst Caregiving Burden Scale). Analyses included ANOVA, Kruskal-Wallis tests, χ2 tests, and linear regression. Results: The majority of caregivers were female, white spouses with ≤ 2 comorbidities, median [Q1,Q3] age = 62 [57.8, 67.0] years. Caregivers (HT with MCS = 87, HT without MCS = 98, long-term MCS = 96) reported similarly high baseline HRQOL (EQ-5D-3L visual analog scale median score = 90; P = 0.67 for all groups) and low levels of depressive symptoms. STAI-state median scores were higher in the long-term MCS group vs the HT groups with and without MCS, (38 vs 32 vs 31; P < 0.001), respectively. Burden (task: time spent/difficulty) differed significantly among groups. Caregiver factors (number of comorbidities, diabetes and higher anxiety levels) were significantly associated with worse caregiver HRQOL, R2 = 26%. Conclusions: Recognizing caregiver-specific factors, including comorbidities and anxiety, associated with the HRQOL of caregivers of these older patients with advanced HF may guide support strategies.
KW - Caregiver
KW - health-related quality of life (HRQOL)
KW - heart failure
KW - heart transplant
KW - mechanical circulatory support
UR - http://www.scopus.com/inward/record.url?scp=85132446721&partnerID=8YFLogxK
U2 - 10.1016/j.cardfail.2022.03.358
DO - 10.1016/j.cardfail.2022.03.358
M3 - Article
C2 - 35470057
AN - SCOPUS:85132446721
SN - 1071-9164
VL - 28
SP - 1137
EP - 1148
JO - Journal of cardiac failure
JF - Journal of cardiac failure
IS - 7
ER -