Baseline Quality-of-Life of Caregivers of Patients With Heart Failure Prior to Advanced Therapies: Findings From the Sustaining Quality of Life of the Aged: Transplant or Mechanical Support (SUSTAIN-IT) Study

M. G. PETTY, T. WU, A. C. ANDREI, A. BALDRIDGE, A. WARZECHA, A. KAO, J. SPERTUS, E. HSICH, M. A. DEW, D. PHAM, C. YANCY, J. HARTUPEE, W. COTTS, S. V. PAMBOUKIAN, F. PAGANI, B. LAMPERT, M. JOHNSON, M. MURRAY, K. TEKEDA, M. YUZEFPOLSKAYAS. SILVESTRY, J. K. KIRKLIN, K. L. GRADY

Research output: Contribution to journalArticlepeer-review

Abstract

Background: We compared health-related quality of life (HRQOL), depressive symptoms, anxiety, and burden in caregivers of older patients with heart failure based on the intended therapy goal of the patient: awaiting heart transplantation (HT) with or without mechanical circulatory support (MCS) or prior to long-term MCS; and we identified factors associated with HRQOL. Methods: Caregivers (n = 281) recruited from 13 HT and MCS programs in the United States completed measures of HRQOL (EQ-5D-3L), depressive symptoms (PHQ-8), anxiety (STAI-state), and burden (Oberst Caregiving Burden Scale). Analyses included ANOVA, Kruskal-Wallis tests, χ2 tests, and linear regression. Results: The majority of caregivers were female, white spouses with ≤ 2 comorbidities, median [Q1,Q3] age = 62 [57.8, 67.0] years. Caregivers (HT with MCS = 87, HT without MCS = 98, long-term MCS = 96) reported similarly high baseline HRQOL (EQ-5D-3L visual analog scale median score = 90; P = 0.67 for all groups) and low levels of depressive symptoms. STAI-state median scores were higher in the long-term MCS group vs the HT groups with and without MCS, (38 vs 32 vs 31; P < 0.001), respectively. Burden (task: time spent/difficulty) differed significantly among groups. Caregiver factors (number of comorbidities, diabetes and higher anxiety levels) were significantly associated with worse caregiver HRQOL, R2 = 26%. Conclusions: Recognizing caregiver-specific factors, including comorbidities and anxiety, associated with the HRQOL of caregivers of these older patients with advanced HF may guide support strategies.

Original languageEnglish
Pages (from-to)1137-1148
Number of pages12
JournalJournal of cardiac failure
Volume28
Issue number7
DOIs
StatePublished - Jul 2022

Keywords

  • Caregiver
  • health-related quality of life (HRQOL)
  • heart failure
  • heart transplant
  • mechanical circulatory support

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