@article{34c8f18ed1c64faa98b7d6b916fb5f9d,
title = "Baseline Lower Urinary Tract Symptoms in Patients Enrolled in LURN: A Prospective, Observational Cohort Study",
abstract = "Purpose: We described and compared the frequency and type of lower urinary tract symptoms reported by men and women at the time that they were recruited from urology and urogynecology clinics into the Symptoms of Lower Urinary Tract Dysfunction Research Network multicenter, prospective, observational cohort study. Materials and Methods: At 6 research sites treatment seeking men and women were enrolled who reported any lower urinary tract symptoms at a frequency more than rarely during the last month on the LUTS (Lower Urinary Tract Symptoms) Tool. At baseline the study participants underwent a standardized clinical evaluation and completed validated questionnaires. Urological tests were performed, including pelvic/rectal examination, post-void residual urine measurement and urinalysis. Results: A total of 545 women and 519 men were enrolled in the study. Mean ± SD age was 58.8 ± 14.1 years. At baseline nocturia, frequency and a sensation of incomplete emptying were similar in men and women but men experienced more voiding symptoms (90% vs 85%, p = 0.007) and women reported more urgency (85% vs 66%, p <0.001). Women also reported more of any type of urinary incontinence than men (82% vs 51% p <0.001), which was mixed incontinence in 57%. Only 1% of men reported stress incontinence but they had other urinary incontinence, including post-void dribbling in 44% and urgency incontinence in 46%. Older participants had higher odds of reporting symptoms of nocturia and urgency. Conclusions: In this large, treatment seeking cohort of men and women lower urinary tract symptoms varied widely by gender and age. Men reported more voiding symptoms and nonstress or urgency urinary incontinence while women reported more incontinence overall and urgency. Older participants had greater odds of urgency and nocturia.",
keywords = "lower urinary tract symptoms, men's health, overactive, urinary bladder, urinary incontinence, women's health",
author = "{Symptoms of Lower Urinary Tract Dysfunction Research Network Study Group} and Cameron, {Anne P.} and Christina Lewicky-Gaupp and Smith, {Abigail R.} and Helfand, {Brian T.} and Gore, {John L.} and Clemens, {J. Quentin} and Yang, {Claire C.} and Siddiqui, {Nazema Y.} and Lai, {H. Henry} and Griffith, {James W.} and Andreev, {Victor P.} and Gang Liu and Kevin Weinfurt and Amundsen, {Cindy L.} and Bradley, {Catherine S.} and Kusek, {John W.} and Ziya Kirkali",
note = "Funding Information: The following individuals were instrumental in study planning and performance at participating institutions: Principle Investigators Drs. Cindy Amundsen and Kevin Weinfurt; Co-Investigators Drs. Kathryn Flynn, Matthew O. Fraser, Todd Harshbarger, Eric Jelovsek, Aaron Lentz, Drew Peterson, Nazema Siddiqui and Alison Weidner; and Study Coordinators Carrie Dombeck, Robin Gilliam, Akira Hayes and Shantae McLean, Duke University, Durham, North Carolina (NIH/NIDDK Grant DK097780); Principle Investigators Drs. Karl Kreder and Catherine S. Bradley; Co-Investigators Drs. Bradley A. Erickson, Susan K. Lutgendorf, Vince Magnotta, Michael A. O{\textquoteright}Donnell and Vivian Sung; and Study Coordinator Ahmad Alzubaidi, University of Iowa, Iowa City, Iowa (NIH/NIDDK Grant DK097772); Principle Investigator David Cella; Co-Investigators Drs. James W. Griffith, Kimberly Kenton, Christina Lewicky-Gaupp, Todd Parrish, Jennie Yufen Chen and Margaret Mueller; and Study Coordinators Sarah Buono, Maria Corona, Beatriz Menendez, Alexis Siurek, Meera Tavathia, Veronica Venezuela and Azra Muftic, Northwestern University, Chicago, Illinois; Principle Investigator Dr. Brian Helfand; and Study Coordinators Pooja Talaty and Jasmine Nero, NorthShore University HealthSystem, Evanston, Illinois (NIH/NIDDK Grant DK097779); Principle Investigator Dr. J. Quentin Clemens; Co-Investigators Drs. Mitch Berger, John DeLancey, Dee Fenner, Rick Harris, Steve Harte, Anne P. Cameron and John Wei; and Study Coordinators Morgen Barroso, Linda Drnek, Greg Mowatt and Julie Tumbarello, University of Michigan Health System, Ann Arbor, Michigan (NIH/NIDDK Grant DK099932); Principle Investigator Dr. Claire Yang; Co-Investigator Dr. John L. Gore; and Study Coordinators Alice Liu and Brenda Vicars, University of Washington, Seattle, Washington (NIH/NIDDK Grant DK100011); Principle Investigators Drs. Gerald L. Andriole and H. Henry Lai; Co-Investigator Dr. Joshua Shimony; and Study Coordinators Susan Mueller, Heather Wilson, Deborah Ksiazek and Aleksandra Klim, Washington University in St. Louis, St. Louis, Missouri (NIH/NIDDK Grant DK100017); Project Scientist Dr. Ziya Kirkali; Project Officer Dr. John Kusek; and NIH Personnel Drs. Tamara Bavendam and Robert Star, and Jenna Norton, Division of Kidney, Urology and Hematology, NIDDK, Bethesda, Maryland; and Principle Investigator Dr. Robert Merion; Co-Investigators Drs. Victor Andreev, Brenda Gillespie, Gang Liu and Abigail Smith; Project Manager Melissa Fava; Clinical Study Process Manager Peg Hill-Callahan; Clinical Monitor Timothy Buck; Research Analysts Margaret Helmuth and Jon Wiseman; and Project Associate Julieanne Lock, Arbor Research Collaborative for Health, Data Coordinating Center (NIH/NIDDK Grants DK097776 and DK099879). Heather Van Doren, Senior Medical Editor, Arbor Research Collaborative for Health, provided editorial assistance. Publisher Copyright: {\textcopyright} 2018 American Urological Association Education and Research, Inc.",
year = "2018",
month = apr,
doi = "10.1016/j.juro.2017.10.035",
language = "English",
volume = "199",
pages = "1023--1031",
journal = "Journal of Urology",
issn = "0022-5347",
number = "4",
}