Baseline Factors Predictive of Incident Penetrating Keratoplasty in Keratoconus

Mae O. Gordon, Karen Steger-May, Loretta Szczotka-Flynn, Colleen Riley, Charlotte E. Joslin, Barry A. Weissman, Barbara A. Fink, Timothy B. Edrington, Harald E. Olafsson, Karla Zadnik

Research output: Contribution to journalArticlepeer-review

115 Scopus citations


Purpose: To identify baseline demographic and clinical factors associated with undergoing penetrating keratoplasty (PK) in a prospective cohort of 1,065 keratoconus patients followed for eight years in the Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study. Design: Multicenter, prospective, observational cohort study. Methods: We report the rate of PK over eight years and baseline factors predictive of PK in 1,065 patients who, at the time of study enrollment, had not undergone PK in either eye. Results: Eighty-two percent of patients completed the eight-year close-out visit. Twelve percent (126 of 1,065) had PK in one (9.3%) or both eyes (2.5%). Baseline factors associated with increased likelihood of PK included younger age, steeper keratometric values, worse visual acuity, corneal scarring, poorer contact lens comfort, and poorer vision-related quality of life. The percent of eyes undergoing PK was 15% for patients 40 years old and younger, 28% for eyes with a steep keratometric value greater than 52 diopters, 33% for visual acuity less than 20/40, and 24% for eyes with corneal scarring. Conclusions: The CLEK Study confirmed previous reports of the increased likelihood of PK associated with corneal scarring, steeper keratometry values, poorer visual acuity, and poorer contact lens comfort. The CLEK Study is among the first to report an increased risk of PK associated with younger age, worse vision-related quality of life, and flatter contact lens fits. Knowledge of these factors is beneficial to clinicians in patient education and may be useful in disease management.

Original languageEnglish
Pages (from-to)923-930.e1
JournalAmerican journal of ophthalmology
Issue number6
StatePublished - Dec 2006


Dive into the research topics of 'Baseline Factors Predictive of Incident Penetrating Keratoplasty in Keratoconus'. Together they form a unique fingerprint.

Cite this