Baseline 6-min walk distance predicts survival in lung transplant candidates

T. Martinu, M. A. Babyak, C. F. O'Connell, R. M. Carney, E. P. Trulock, R. D. Davis, J. A. Blumenthal, S. M. Palmer

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65 Scopus citations


In a large, prospectively followed, two-center cohort of patients listed for lung transplantation (n = 376), we used Cox proportional hazards models to determine the importance of baseline 6-min walk distance (6MWD) in predicting patient survival. 6MWD used as a continuous variable was a significant predictor of survival after adjusting for other important covariates when transplant was considered as a time-varying covariate (HR for each 500 ft increase in 6MWD = 0.57, 95% CI: 0.43-0.77, p = 0.0002). 6MWD remained an important predictor of survival in models that considered only survival to transplant (HR for each 500 ft increase in 6MWD = 0.41, 95% CI: 0.27-0.62, p < 0.0001) or survival only after transplant (HR for each 500 ft increase in 6MWD = 0.40, 95% CI: 0.22-0.72, p = 0.002). Unadjusted Kaplan-Meier analysis demonstrates significantly different survival by 6MWD tertiles (<900, 900-1200, or >1200 ft, p-value = 0.0001). In the overall model, 6MWD prediction of survival was relatively homogeneous across disease category (6MWD by disease interaction term, p-value = 0.63). Our results demonstrate a significant relationship between baseline 6MWD and survival among patients listed for lung transplantation that exists across all native disease categories and extends through transplantation. The 6MWD is thus a useful measure of both urgency and utility among patients awaiting lung transplantation.

Original languageEnglish
Pages (from-to)1498-1505
Number of pages8
JournalAmerican Journal of Transplantation
Issue number7
StatePublished - Jul 2008


  • Exercise capacity
  • Exercise testing
  • Lung
  • Lung transplantation
  • Posttransplantation
  • Pretransplant
  • Prognosis
  • Prognostic factors survival
  • Survival analysis


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