Banff Lung Report: Current knowledge and future research perspectives for diagnosis and treatment of pulmonary antibody-mediated rejection (AMR)

A. Roux; D. J. Levine; A. Zeevi; R. Hachem; K. Halloran; P. F. Halloran; L. Gibault; J. L. Taupin; D. A.H. Neil; A. Loupy; B. A. Adam; M. Mengel; D. M. Hwang; F. Calabrese; G. Berry; E. N. Pavlisko

doi:10.1111/ajt.14990

Banff Lung Report: Current knowledge and future research perspectives for diagnosis and treatment of pulmonary antibody-mediated rejection (AMR)

A. Roux, D. J. Levine, A. Zeevi, R. Hachem, K. Halloran, P. F. Halloran, L. Gibault, J. L. Taupin, D. A.H. Neil, A. Loupy, B. A. Adam, M. Mengel, D. M. Hwang, F. Calabrese, G. Berry, E. N. Pavlisko

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Abstract

The Lung session of the 2017 14th Banff Foundation for Allograft Pathology Conference, Barcelona focused on the multiple aspects of antibody-mediated rejection (AMR) in lung transplantation. Multidimensional approaches for AMR diagnosis, including classification, histological and immunohistochemical analysis, and donor- specific antibody (DSA) characterization with their current strengths and limitations were reviewed in view of recent research. The group also discussed the role of tissue gene expression analysis in the context of unmet needs in lung transplantation. The current best practice for monitoring of AMR and the therapeutic approach are summarized and highlighted in this report. The working group reached consensus of the major gaps in current knowledge and focused on the unanswered questions regarding pulmonary AMR. An important outcome of the meeting was agreement on the need for future collaborative research projects to address these gaps in the field of lung transplantation.

Original language	English
Pages (from-to)	21-31
Number of pages	11
Journal	American Journal of Transplantation
Volume	19
Issue number	1
DOIs	https://doi.org/10.1111/ajt.14990
State	Published - Jan 2019

Keywords

alloantibody
classification systems: Banff classification
clinical research/practice
histocompatibility
lung (allograft) function/dysfunction
lung transplantation/pulmonology
microarray/gene array
pathology/histopathology
rejection: antibody-mediated (ABMR)

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10.1111/ajt.14990

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Roux, A., Levine, D. J., Zeevi, A., Hachem, R., Halloran, K., Halloran, P. F., Gibault, L., Taupin, J. L., Neil, D. A. H., Loupy, A., Adam, B. A., Mengel, M., Hwang, D. M., Calabrese, F., Berry, G., & Pavlisko, E. N. (2019). Banff Lung Report: Current knowledge and future research perspectives for diagnosis and treatment of pulmonary antibody-mediated rejection (AMR). American Journal of Transplantation, 19(1), 21-31. https://doi.org/10.1111/ajt.14990

@article{befe054f3f8b4ad9a6c69ed0723b5ebc,

title = "Banff Lung Report: Current knowledge and future research perspectives for diagnosis and treatment of pulmonary antibody-mediated rejection (AMR)",

abstract = "The Lung session of the 2017 14th Banff Foundation for Allograft Pathology Conference, Barcelona focused on the multiple aspects of antibody-mediated rejection (AMR) in lung transplantation. Multidimensional approaches for AMR diagnosis, including classification, histological and immunohistochemical analysis, and donor- specific antibody (DSA) characterization with their current strengths and limitations were reviewed in view of recent research. The group also discussed the role of tissue gene expression analysis in the context of unmet needs in lung transplantation. The current best practice for monitoring of AMR and the therapeutic approach are summarized and highlighted in this report. The working group reached consensus of the major gaps in current knowledge and focused on the unanswered questions regarding pulmonary AMR. An important outcome of the meeting was agreement on the need for future collaborative research projects to address these gaps in the field of lung transplantation.",

keywords = "alloantibody, classification systems: Banff classification, clinical research/practice, histocompatibility, lung (allograft) function/dysfunction, lung transplantation/pulmonology, microarray/gene array, pathology/histopathology, rejection: antibody-mediated (ABMR)",

author = "A. Roux and Levine, {D. J.} and A. Zeevi and R. Hachem and K. Halloran and Halloran, {P. F.} and L. Gibault and Taupin, {J. L.} and Neil, {D. A.H.} and A. Loupy and Adam, {B. A.} and M. Mengel and Hwang, {D. M.} and F. Calabrese and G. Berry and Pavlisko, {E. N.}",

note = "Publisher Copyright: {\textcopyright} 2018 The American Society of Transplantation and the American Society of Transplant Surgeons",

year = "2019",

month = jan,

doi = "10.1111/ajt.14990",

language = "English",

volume = "19",

pages = "21--31",

journal = "American Journal of Transplantation",

issn = "1600-6135",

number = "1",

}

Roux, A, Levine, DJ, Zeevi, A, Hachem, R, Halloran, K, Halloran, PF, Gibault, L, Taupin, JL, Neil, DAH, Loupy, A, Adam, BA, Mengel, M, Hwang, DM, Calabrese, F, Berry, G & Pavlisko, EN 2019, 'Banff Lung Report: Current knowledge and future research perspectives for diagnosis and treatment of pulmonary antibody-mediated rejection (AMR)', American Journal of Transplantation, vol. 19, no. 1, pp. 21-31. https://doi.org/10.1111/ajt.14990

TY - JOUR

T1 - Banff Lung Report

T2 - Current knowledge and future research perspectives for diagnosis and treatment of pulmonary antibody-mediated rejection (AMR)

AU - Roux, A.

AU - Levine, D. J.

AU - Zeevi, A.

AU - Hachem, R.

AU - Halloran, K.

AU - Halloran, P. F.

AU - Gibault, L.

AU - Taupin, J. L.

AU - Neil, D. A.H.

AU - Loupy, A.

AU - Adam, B. A.

AU - Mengel, M.

AU - Hwang, D. M.

AU - Calabrese, F.

AU - Berry, G.

AU - Pavlisko, E. N.

PY - 2019/1

Y1 - 2019/1

N2 - The Lung session of the 2017 14th Banff Foundation for Allograft Pathology Conference, Barcelona focused on the multiple aspects of antibody-mediated rejection (AMR) in lung transplantation. Multidimensional approaches for AMR diagnosis, including classification, histological and immunohistochemical analysis, and donor- specific antibody (DSA) characterization with their current strengths and limitations were reviewed in view of recent research. The group also discussed the role of tissue gene expression analysis in the context of unmet needs in lung transplantation. The current best practice for monitoring of AMR and the therapeutic approach are summarized and highlighted in this report. The working group reached consensus of the major gaps in current knowledge and focused on the unanswered questions regarding pulmonary AMR. An important outcome of the meeting was agreement on the need for future collaborative research projects to address these gaps in the field of lung transplantation.

AB - The Lung session of the 2017 14th Banff Foundation for Allograft Pathology Conference, Barcelona focused on the multiple aspects of antibody-mediated rejection (AMR) in lung transplantation. Multidimensional approaches for AMR diagnosis, including classification, histological and immunohistochemical analysis, and donor- specific antibody (DSA) characterization with their current strengths and limitations were reviewed in view of recent research. The group also discussed the role of tissue gene expression analysis in the context of unmet needs in lung transplantation. The current best practice for monitoring of AMR and the therapeutic approach are summarized and highlighted in this report. The working group reached consensus of the major gaps in current knowledge and focused on the unanswered questions regarding pulmonary AMR. An important outcome of the meeting was agreement on the need for future collaborative research projects to address these gaps in the field of lung transplantation.

KW - alloantibody

KW - classification systems: Banff classification

KW - clinical research/practice

KW - histocompatibility

KW - lung (allograft) function/dysfunction

KW - lung transplantation/pulmonology

KW - microarray/gene array

KW - pathology/histopathology

KW - rejection: antibody-mediated (ABMR)

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U2 - 10.1111/ajt.14990

DO - 10.1111/ajt.14990

M3 - Article

C2 - 29956477

AN - SCOPUS:85053191719

SN - 1600-6135

VL - 19

SP - 21

EP - 31

JO - American Journal of Transplantation

JF - American Journal of Transplantation

IS - 1

ER -

Banff Lung Report: Current knowledge and future research perspectives for diagnosis and treatment of pulmonary antibody-mediated rejection (AMR)

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Keywords

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