BAllC and BAllCools: efficient formatting and operating for single-cell DNA methylation data

Wei Tian, Wubin Ding, Jiawei Shen, Daofeng Li, Ting Wang, Joseph R. Ecker

Research output: Contribution to journalArticlepeer-review

Abstract

Motivation: With single-cell DNA methylation studies yielding vast datasets, existing data formats struggle with the unique challenges of storage and efficient operations, highlighting a need for improved solutions. Results: BAllC (Binary All Cytosines) emerges as a tailored format for methylation data, addressing these challenges. BAllCools, its complementary software toolkit, enhances parsing, indexing, and querying capabilities, promising superior operational speeds and reduced storage needs.

Original languageEnglish
Article numberbtae404
JournalBioinformatics
Volume40
Issue number7
DOIs
StatePublished - Jul 1 2024

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