Balancing serendipity and reproducibility: Pluripotent stem cells as experimental systems for intellectual and developmental disorders

Cross-IDDRC Human Stem Cell Working Group

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) and their differentiation into neural lineages is a revolutionary experimental system for studying neurological disorders, including intellectual and developmental disabilities (IDDs). However, issues related to variability and reproducibility have hindered translating preclinical findings into drug discovery. Here, we identify areas for improvement by conducting a comprehensive review of 58 research articles that utilized iPSC-derived neural cells to investigate genetically defined IDDs. Based upon these findings, we propose recommendations for best practices that can be adopted by research scientists as well as journal editors.

Original languageEnglish
Pages (from-to)1446-1457
Number of pages12
JournalStem Cell Reports
Volume16
Issue number6
DOIs
StatePublished - Jun 8 2021

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